34161-23-4

• 常用中文名：Fipexide hydrochloride
• 常用英文名：Attentil
• CAS号：34161-23-4
• 分子式：C₂₀H₂₂Cl₂N₂O₄
• 分子量：425.30600
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 腺苷酸环化酶
• 发布时间：2016-06-01 21:58:43
• 更新时间：2024-01-30 09:43:13
• Fipexide hydrochloride 是对氯苯乙酸衍生物,是一种促智药物。Fipexide hydrochloride 降低了纹状体腺苷酸环化酶 (adenylate cyclase) 的活性。Fipexide hydrochloride 通过多巴胺能神经传递对认知表现出积极的作用。Fipexide hydrochloride 具有用于老年痴呆研究的潜力。

名称

• 中文名: 非哌西特盐酸盐
• 英文名: fipexide hydrochloride
• 英文别名: 1-[2-(4-CHLOROPHENOXY)ACETYL]-4-[3,4-METHYLENEDIOXYBENZYL]PIPERAZINE HYDROCHLORIDE; 1-(3',4'-methylenedioxybenzyl)-4-(4-chlorophenoxyacetyl)-piperazine hydrochloride; 1-(1,3-benzodioxol-5-ylmethyl)-4-[(4-chlorophenoxy)acetyl]piperazinium chloride; Vigilor; 1-(1,3-Benzodioxol-5-yl-methyl)-4-[(4-chlorophenoxy)acetyl]piperazine hydrochloride; Attentil; 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-chlorophenoxy)ethanone hydrochloride; BP-662

物化性质

• 密度: 1.342g/cm3
• 沸点: 559.3ºC at 760 mmHg
• 分子式: C₂₀H₂₂Cl₂N₂O₄
• 分子量: 425.30600
• 闪点: 292.1ºC
• 精确质量: 424.09600
• PSA: 51.24000
• LogP: 3.46970
• 储存条件: -20°C

生物活性

• 描述: Fipexide hydrochloride 是对氯苯乙酸衍生物,是一种促智药物。Fipexide hydrochloride 降低了纹状体腺苷酸环化酶 (adenylate cyclase) 的活性。Fipexide hydrochloride 通过多巴胺能神经传递对认知表现出积极的作用。Fipexide hydrochloride 具有用于老年痴呆研究的潜力。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷酸环化酶
  信号通路 >> 神经信号通路 >> 多巴胺转运蛋白
  研究领域 >> 神经疾病
• 参考文献:

  [1]. A Marino, et al. Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies. Pharmacol Res. Mar-Apr 1990;22(2):179-87.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TK8220100 CHEMICAL NAME : Piperazine, 1-(1,3-benzodioxol-5-ylmethyl)-4-((4-chlorophenoxy)ac etyl)-, monohydrochloride CAS REGISTRY NUMBER : 34161-23-4 LAST UPDATED : 199009 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C20-H21-Cl-N2-O4.Cl-H MOLECULAR WEIGHT : 425.34 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4482 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : ACTTDZ Acta Therapeutica. (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium) V.1- 1975- Volume(issue)/page/year: 11,387,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : ACTTDZ Acta Therapeutica. (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium) V.1- 1975- Volume(issue)/page/year: 11,387,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4150 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : ACTTDZ Acta Therapeutica. (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium) V.1- 1975- Volume(issue)/page/year: 11,387,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 499 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : ACTTDZ Acta Therapeutica. (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium) V.1- 1975- Volume(issue)/page/year: 11,387,1985

安全

• 危害码 (欧洲): Xn

合成路线

4122-68-3 55436-41-4 ~61% 34161-23-4

文献：Gardini, G. P.; Palla, G.; Scapini, G.; Cesaroni, M. R. Synthetic Communications, 1982 , vol. 12, # 11 p. 887 - 890

20850-43-5 ~% 34161-23-4

文献：Gardini, G. P.; Palla, G.; Scapini, G.; Cesaroni, M. R. Synthetic Communications, 1982 , vol. 12, # 11 p. 887 - 890

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