70288-86-7
70288-86-7 structure
- Name: Ivermectin
- Chemical Name: ivermectin
- CAS Number: 70288-86-7
- Molecular Formula: C48H74O14
- Molecular Weight: 875.09300
- Catalog: API Antiparasitic drug Resistance to filariasis and anti-leishmaniasis
- Create Date: 2018-02-08 08:00:00
- Modify Date: 2026-07-01 19:22:08
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Ivermectin is a widely used antiparasitic agent in human and veterinary medicine. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs).
| Name | ivermectin |
|---|---|
| Synonyms |
Ivermectin G0D4080.906mg/mg(ai)
IvetMectin Ivosint Stromectol hetgd-30 VERMECTIN EINECS 274-536-0 MFCD00869511 Ivermectine 0 EQVALEN 23-Dihydroavermectin B1 hyvermectin IVERMECTIN 22，23-Dihydro C-076 Bla 22,23-Dihydroavermectin B1, MK-933 Ivermectin@1000 μg/mL in Acetonitrile Cdotek-30：Eqvalan (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5,11',13',22'-tetramethyl-6-[(1S)-1-methylpropyl]-3,4,5,6-tetrahydro-2'H-spiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1.0]pentacosa[10,14,16,22]tetraen]-2'-one IVERMECTIN (CRM STANDD) CARDOMEC Uvemec (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-Methoxy-6-Methyloxan-2-yl]oxy}-4-Methoxy-6-Methyloxan-2-yl]oxy}-5,11',13',22'-tetraMethyl-6-(propan-2-yl)-3',7',19'-trioxasp Ivermectin@100 μg/mL in Acetonitrile Lvermectin1 Ivermectin CRS Ivermectin 2000 22，23-Dihydroabamectin Ivermectine2000 Avermectin B1a Dihydro Analog Ivermectin 70-7 High purity Ivermectin in stock CAS NO.70-7 CAS NO.70-7 22,23-Dihydro C-076B1 mk933 IVERMECTIN HCL 5-O-Demethyl-22，23-dihydmavermectin Ala Mectizan IverMectin COS mk-0933 Ivermectin, >= Cdomec(TM) 22,23-Dihydroavemectin B1 IVOMEC Ivermectine Ivermecti Vermic Ivermectin (EDMF) CDOMEC 22,23-DIHYDROAVERMECTINE Ivermectin,22,23-Dihydroavermectin B1, MK-933 Zimecterin 22，23-Dihydroavermectin Blb 22,23-dihydroavermectin B1 22，23-Dihydroavermectin Bla IverMectin(FDA) IVERMECTIN NOT LESS THAN OF 22,23-DIHY- DROAVERMECTIN B1A, AND NOT LESS THAN OF 22,23-DIHY-DROAVERMECTIN B1(B1A+B1B) 22,23-DIHYDROAVERMECTIN B1 22，23-Dihydro C-176B IVERMECTINE(PATENT-NOSUPPLY) |
| Description | Ivermectin is a widely used antiparasitic agent in human and veterinary medicine. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). |
|---|---|
| Related Catalog | |
| In Vitro | Ivermectin (IVM) is a specific positive allosteric effector of heterologously expressed P2X4 and possibly of heteromeric P2X4/ P2X6 channels. In the submicromolar range (EC50=250 nM) the action of IVM is rapid and reversible, resulting in increased amplitude and slowed deactivation of P2X4 channel currents evoked by ATP. IVM also markedly increases the potency of ATP and that of the normally low-potency agonist a,b-methylene-ATP in a use- and voltage-independent manner without changing the ion selectivity of P2X4 channels[1]. IVM activates glutamate-gated chloride channels in the nerves and muscles of the parasite, leading to membrane hyperpolarization and muscle paralysis. The major mode of action of IVM is most likely the disruption of ingestive activity of the parasite, resulting in starvation[2]. Preapplication of ivermectin, in the micromolar range, strongly enhances the subsequent acetylcholine-evoked current of the neuronal chick or human α7 nicotinic acetylcholine receptors reconstituted in Xenopus laevis oocytes and K-28 cells[3]. Ivermectin activates the rat recombinant α1β2γ2s GABAA receptor. Activation of the channel with 10 mM GABA results in currents rising within 1 ms to their maximal amplitudes. The EC50 value for GABA is 7.5 μM[4]. |
| References |
| Melting Point | 155 °C |
|---|---|
| Molecular Formula | C48H74O14 |
| Molecular Weight | 875.09300 |
| Exact Mass | 874.50800 |
| PSA | 170.06000 |
| LogP | 5.60140 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: ≤1.0% KF |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | Missing Phrase - N15.00950417 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic; |
| Risk Phrases | 61-25-36-36/38-22 |
| Safety Phrases | 53-26-45-36 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
| HS Code | 2932999099 |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |