Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Olmesartan medoxomil
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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144689-63-4

144689-63-4 structure

144689-63-4 structure

Name: Olmesartan medoxomil
Chemical Name: Olmesartan medoxomil
CAS Number: 144689-63-4
Molecular Formula: C₂₉H₃₀N₆O₆
Molecular Weight: 558.585
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-08-22 20:32:17
Modify Date: 2026-06-30 19:57:38
Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.

Name	Olmesartan medoxomil
Synonyms	Olmestan MedoxomiI OlMestan MedoxoMil SynoyM:4-(1-Hydroxy-1-Methylethyl)-2-propyl-1-[[2'-(1H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-iMidazole-5-cboxylic acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester MFCD00914967 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2’-(2H-tetazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-cboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester OLEMISTAN MEDAXMIL Benic Benzenesulfonylchloride,8-(acetylamino) Olmetec Olmestan medoxomil for system suitability CRS Olmestan Medoxomil: (5-Methyl-2-oxo-1,3-dioxol-4-yl) methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-cboxylate 1H-imidazole-5-cboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester Omestan ester OLMESTAN MEDOXOMIL ORGANIC CHEMICA (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-cboxylate 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-cboxylicacid(5-Methyl-2-oxo-1,3-dioxol-4-yl)methylester 1H-imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester 4-(1-Hydroxy-isopropyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]methyl]-1H-imidazol-5-cboxylic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)methyl ester Olmestan medoxomil CRS (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate Olmestan medoxomil Olmestan Medoxomile (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate Sanguisorba officinalis L olmestan medoxomil olmetec 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2’-(1h-tetazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1h-imidazole-5-cboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl esterEuEEuE Benicar Olmestan Medoxomil RS 5-(1-Hydroxy-1-methylethyl)-2-propyl-3-[2'-(1H-tet Olmestan Medoxomil //BP (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2Htetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-cboxylate 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolecboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl-4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-carboxylat Good Quality Olmestan Medoxomil CAS144-4Omst for Anti-Hypertensive Olmestan API Oimestan olmestan medoxomil olmetec 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1h-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-cboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl esterEuEE OlMestan MedoxoMil (Benic Olmestan Medoxomil, 10 mM in DMSO OlmestanC29H30N6O6 4-(1-hydroxy-1-méthyléthyl)-2-propyl-1-{[2'-(2H-tétrazol-5-yl)biphényl-4-yl]méthyl}-1H-imidazole-5-carboxylate de (5-méthyl-2-oxo-1,3-dioxol-4-yl)méthyle (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hyd Olmestan MedoxomilQ: What is Olmestan Medoxomil Q: What is the CAS Number of Olmestan Medoxomil Q: What is the storage condition of Olmestan Medoxomil 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester Olmesartan Medoxomil (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl] 4-yl)methyl)-4-( 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl-1H-Imidazole-5-cboxylic acid, (5-methyl -2-oxo-1,3-dioxol-4-yl) methyl ester OLMESTAN MEDOXOMIL ANULES Olmestan Medoxomil (5-Methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan- 2-yl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5- yl)phenyl]phenyl}methyl)-1H-imidazole-5-cboxylate Olmestn Medoxomil (5-Methyl-2-oxo-2H-1,3-dioxol-4-yl)Methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1H-iMidazole-5-cboxylate Olmestan medoxomil for system suitability OLMESTAN MEDOXIMIL (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylate (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate 5-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-3-[2''-(1H-TETRAZOL-5-YL)-BIPHENYL-4-YLMETHYL]-3H-IMIDAZOLE-4-CBOXYLIC ACID 5-METHYL-2-OXO-[1,3]DIOXOL-4-YLMETHYL ESTER Olmestan Medoxomi (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-cboxylate Benevas Olmestan medoxomil API Olmestan medoxomil (Y0001405)

Description	Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease
Target	IC50: 66.2 μM (angiotensin II receptor)[1]
In Vitro	Inhibition of Arachidonic acid (AA) metabolism by angiotensin II receptor blockers (ARBs) is detected in a concentration-dependent manner with IC50 of Olmesartan (66.2 μM)[1]. Olmesartan medoxomil (OLM) is a potent and selective angiotensin AT1 receptor blocker[2].
In Vivo	The efficacy of Olmesartan (20 mg/kg) studied in db/db diabetic mice for a period of 12 weeks starting from week 10 to 12 of age. The db/db mice have 11.7 fold increased albuminuria in comparison to control mice at week 22 to 24 of age. Twelve weeks Olmesartan administration significantly reduces albuminuria in db/db mice by 77% as compared with placebo treated db/db mice. The albumin/creatinine ratio (ACR) is increased in db/db mice in comparison to control mice by 7.1 fold and Olmesartan treatment significantly decreases ACR by 59% in db/db mice[3].
Animal Admin	Mice[3] 10 to 12-week old male db/db diabetic mice with background strain C57BL/KsJ and their age-matched non-diabetic lean control mice (C57BL) are used.10 non-diabetic control mice and 10 diabetic mice are fed with placebo (0.5% sodium CMC/saline solution), and 10 diabetic mice are fed with 20 mg/kg Olmesartan (MB5704) by daily gavage for 12 weeks. Mice are monitored for blood glucose, body weight and urine output every two weeks. After treatment, mice are euthanized and trunk blood is collected and is centrifuged to obtain plasma which is aliquoted and stored at -80°C. Kidney tissues are removed from mice. For protein extraction slices of the kidney tissue are frozen in liquid nitrogen, and stored at -80°C. Other parts of the kidney tissue are fixed with 4% paraformaldehyde and embedded in paraffin for immunostaining.
References	[1]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9. [2]. Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Pharm. 2012 Apr;4(2):88-94. [3]. Gu J, et al. Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis. Kidney Blood Press Res. 2016 Nov 21;41(6):848-864.

Density	1.4±0.1 g/cm3
Boiling Point	804.2±75.0 °C at 760 mmHg
Melting Point	180°C
Molecular Formula	C₂₉H₃₀N₆O₆
Molecular Weight	558.585
Flash Point	440.2±37.1 °C
Exact Mass	558.222656
PSA	162.16000
LogP	5.23
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.661
Storage condition	-20°C Freezer

Hazard Codes	Xi
Risk Phrases	R36/38:Irritating to eyes and skin . R41:Risk of serious damage to eyes. R38:Irritating to the skin.
Safety Phrases	S37/39-S26-S39
RIDADR	NONH for all modes of transport
RTECS	NI4014200
HS Code	2934999090

Precursor 10
144690-92-6 144690-33-5 80841-78-7 1020157-01-0
144689-93-0 124750-51-2 58954-23-7 133051-88-4
144689-94-1 172875-59-1
DownStream 1
879562-26-2

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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