124168-73-6

124168-73-6 structure

Name: 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt
Chemical Name: 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid
CAS Number: 124168-73-6
Molecular Formula: C₂₃H₃₄N₆O₆
Molecular Weight: 490.553
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2018-10-05 11:33:37
Modify Date: 2024-01-08 17:14:34
FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation[1][2].

Name	4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid
Synonyms	D-Alaninamide, N-(4-aminobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy- 1-[2-[(4-aminobenzoyl)amino]acetyl]-N-[1-[[1-(hydroxyamino)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide MFCD00237459 N-(4-Aminobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy-D-alaninamide

Description	FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
In Vitro	FN-439 inhibits collagenase-1 with an IC50 value of 1 μM[1]. FN-439 (1 μM) reduces the invasive potential of MDA-MB-231 breast cancer cells[1].
In Vivo	FN-439 significantly decreases neutrophils and macrophages, shows extensive bone formation and active cementogenesis in the periapical region when has a combination with ofloxaci[2].

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