Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3-Indolepropionic acid
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Purity: 99.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 3-Indolepropionic acid
Price: ￥408.0/100g ￥138.0/25g
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Indole-3-propionic acid
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Purity: 98.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Indole-3-propionic acid
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-Indolepropionic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

830-96-6

830-96-6 structure

830-96-6 structure

Name: 3-Indolepropionic acid
Chemical Name: 3-(1H-indol-3-yl)propanoic acid
CAS Number: 830-96-6
Molecular Formula: C₁₁H₁₁NO₂
Molecular Weight: 189.210
Catalog: Research Areas Metabolic Disease
Create Date: 2018-03-04 08:00:00
Modify Date: 2024-01-02 19:18:16
3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

Name	3-(1H-indol-3-yl)propanoic acid
Synonyms	3-Indolepropionic acid MFCD00005660 1H-Indole-3-propanoic acid 3-(1H-Indol-3-yl)propanoic acid b-(3-Indolyl)propionic acid Indole-3-propionic acid EINECS 212-600-1 3-(1H-Indol-3-yl)propionic acid IPA

Description	3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
Related Catalog	Natural Products >> Saccharides and Glycosides Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
In Vitro	3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease[1]. 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds[2]. It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function[3].
References	[1]. Wikoff WR, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703. [2]. Reiter RJ, et al. Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Ann N Y Acad Sci. 1998 Nov 20;854:410-24. [3]. de Mello VDet al. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Sci Rep. 2017 Apr 11;7:46337. doi: 10.1038/srep46337.

Density	1.3±0.1 g/cm3
Boiling Point	417.6±20.0 °C at 760 mmHg
Melting Point	134-135 °C(lit.)
Molecular Formula	C₁₁H₁₁NO₂
Molecular Weight	189.210
Flash Point	206.4±21.8 °C
Exact Mass	189.078979
PSA	53.09000
LogP	1.76
Vapour density	2.1 (vs air)
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.667
Storage condition	−20°C
Water Solubility	slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM1329000

CHEMICAL NAME :: 1H-Indole-3-propionic acid

CAS REGISTRY NUMBER :: 830-96-6

BEILSTEIN REFERENCE NO. :: 0147733

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H11-N-O2

MOLECULAR WEIGHT :: 189.23

WISWESSER LINE NOTATION :: T56 BMJ D2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 34,138,1936

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R22;R36/37/38
Safety Phrases	S7-S16-S24/25-S26-S36/37-S37/39-S22
RIDADR	UN 1987 3/PG 3
WGK Germany	3
RTECS	NT8050000
HS Code	29339990

Precursor 9
120-72-9 79-10-7 10184-98-2 4361-05-1
31529-28-9 109897-76-9 85612-35-7 10075-50-0
5457-31-8
DownStream 10
1050443-69-0 3569-21-9 141071-79-6 20401-90-5
219544-69-1 2387-23-7 60586-98-3 3456-99-3
6245-89-2 5814-93-7

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%