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830-96-6

830-96-6 structure
830-96-6 structure
  • Name: 3-Indolepropionic acid
  • Chemical Name: 3-(1H-indol-3-yl)propanoic acid
  • CAS Number: 830-96-6
  • Molecular Formula: C11H11NO2
  • Molecular Weight: 189.210
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2018-03-04 08:00:00
  • Modify Date: 2025-08-20 10:36:43
  • 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
Name 3-(1H-indol-3-yl)propanoic acid
Synonyms 3-Indolepropionic acid
MFCD00005660
1H-Indole-3-propanoic acid
3-(1H-Indol-3-yl)propanoic acid
b-(3-Indolyl)propionic acid
Indole-3-propionic acid
EINECS 212-600-1
3-(1H-Indol-3-yl)propionic acid
IPA
Description 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease[1]. 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds[2]. It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function[3].
References

[1]. Wikoff WR, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703.

[2]. Reiter RJ, et al. Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Ann N Y Acad Sci. 1998 Nov 20;854:410-24.

[3]. de Mello VDet al. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Sci Rep. 2017 Apr 11;7:46337. doi: 10.1038/srep46337.
Density 1.3±0.1 g/cm3
Boiling Point 417.6±20.0 °C at 760 mmHg
Melting Point 134-135 °C(lit.)
Molecular Formula C11H11NO2
Molecular Weight 189.210
Flash Point 206.4±21.8 °C
Exact Mass 189.078979
PSA 53.09000
LogP 1.76
Vapour density 2.1 (vs air)
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.667
Storage condition −20°C
Water Solubility slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NM1329000
CHEMICAL NAME :
1H-Indole-3-propionic acid
CAS REGISTRY NUMBER :
830-96-6
BEILSTEIN REFERENCE NO. :
0147733
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C11-H11-N-O2
MOLECULAR WEIGHT :
189.23
WISWESSER LINE NOTATION :
T56 BMJ D2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 34,138,1936
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R22;R36/37/38
Safety Phrases S7-S16-S24/25-S26-S36/37-S37/39-S22
RIDADR UN 1987 3/PG 3
WGK Germany 3
RTECS NT8050000
HS Code 29339990
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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