Name | Etazolate hydrochloride |
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Synonyms | Ethyl 1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate monohydrochloride |
Description | Etazolate hydrochloride (SQ 20009) is an orally active, selective inhibitor of type 4 phosphodiesterase (PDE4) with an IC50 of 2 μM. Etazolate hydrochloride is a γ-aminobutyric acid A (GABAA) receptor regulator. Etazolate hydrochloride is an α-secretase activator and induced the production of soluble amyloid precursor protein (sAPPα). Etazolate hydrochloride, a pyrazolopyridine class derivative, increases cAMP levels. Etazolate hydrochloride has anxiolyticlike, antidepressant-like and anti-inflammatory effects[1][2][3][4][5]. |
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Related Catalog | |
Target |
PDE4:2 μM (IC50) |
In Vitro | Etazolate hydrochloride (SQ 20009; 25 µM) 在 LtT7.TR 细胞中显着增加精氨酸酶和 ODC 蛋白质水平的表达(精氨酸酶和 ODC 分别为~3.1 倍和~1.6 倍) [2]。 |
In Vivo | Etazolate hydrochloride (SQ 20009; 1, 3, 10 mg/kg; 腹腔给药) 在小鼠创伤性脑损伤 (TBI) 后持续改善识别记忆并减少运动过度活跃[3]。 Etazolate hydrochloride (0.5, 1 mg/kg; 灌胃给药; 每天一次; 21 天) 在瑞士白化小鼠 (22-25 g)中显着抑制慢性不可预知的轻度应激 (CUMS) 诱导的行为 (减少蔗糖消耗并增加不动的持续时间) 和生化 (增加脂质过氧化和亚硝酸盐水平;降低谷胱甘肽、超氧化物歧化酶和过氧化氢酶活性) 的变化[4]。 Etazolate hydrochloride (0.5, 1 mg/kg; 腹腔注射; 单次) 在雄性 Wistar 大鼠 (250-275 g) 中拮抗 Reserpine (HY-N0480; 1 mg/kg;腹腔注射) 诱导的体温过低[5]< /sup>。 Animal Model: Male Swiss mice with 28-30 g[3] Dosage: 1, 3, 10 mg/kg Administration: IP Result: Reduced cerebral œdema when delivered 5 min and 2 h post-TBI. Improved recognition memory and reduces locomotor hyperactivity in a persistent manner following TBI. |
References |
Density | 1.25g/cm3 |
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Boiling Point | 427.6ºC at 760mmHg |
Molecular Formula | C14H20ClN5O2 |
Molecular Weight | 325.79400 |
Flash Point | 212.4ºC |
Exact Mass | 325.13100 |
PSA | 81.40000 |
LogP | 3.31060 |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi: Irritant; |
Risk Phrases | R36/37/38 |
RIDADR | NONH for all modes of transport |