1211-19-4
1211-19-4 structure
- Name: SIRT-IN-3
- Chemical Name: 2-anilinobenzamide
- CAS Number: 1211-19-4
- Molecular Formula: C13H12N2O
- Molecular Weight: 212.24700
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2017-02-27 14:14:35
- Modify Date: 2024-01-10 09:32:34
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SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1].
| Name | 2-anilinobenzamide |
|---|---|
| Synonyms |
N-phenyl-anthranilic acid amide
Benzamide,o-anilino N-Phenyl-anthranilsaeure-amid Anilinobenzamide N-phenylanthranylamide N-phenylanthranilamide |
| Description | SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells[1]. |
| References |
[1]. Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1(10):1059-62. |
| Density | 1.218g/cm3 |
|---|---|
| Boiling Point | 413.3ºC at 760 mmHg |
| Molecular Formula | C13H12N2O |
| Molecular Weight | 212.24700 |
| Flash Point | 203.8ºC |
| Exact Mass | 212.09500 |
| PSA | 55.12000 |
| LogP | 3.30240 |
| Vapour Pressure | 4.84E-07mmHg at 25°C |
| Index of Refraction | 1.663 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2924299090 |
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|
~80%
1211-19-4 |
| Literature: Huang, Xiaohua; Anderson, Kevin W.; Zim, Danilo; Jiang, Lei; Klapars, Artis; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6653 - 6655 |
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~0%
1211-19-4 |
| Literature: Huang, Xiaohua; Anderson, Kevin W.; Zim, Danilo; Jiang, Lei; Klapars, Artis; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6653 - 6655 |
|
~58%
1211-19-4 |
| Literature: Maruyama; Kawata; Ono; Nishizawa; Ito; Inoue Bioscience, biotechnology, and biochemistry, 2001 , vol. 65, # 8 p. 1761 - 1765 |
|
~%
1211-19-4 |
| Literature: ROCHE DIAGNOSTICS GMBH; F. HOFFMANN-LA ROCHE AG Patent: WO2008/52742 A1, 2008 ; Location in patent: Page/Page column 17; Sheet 1 ; |
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~%
1211-19-4 |
| Literature: Goodman; Arbiter; Powell Journal of the American Chemical Society, 1933 , vol. 55, p. 4294,4297, 4298 |
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~%
1211-19-4 |
| Literature: Coyne,W.E.; Cusic,J.W. Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1208 - 1213 |
| Precursor 6 | |
|---|---|
| DownStream 4 | |
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |