SIRT-IN-3
SIRT-IN-3 structure
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Common Name | SIRT-IN-3 | ||
|---|---|---|---|---|
| CAS Number | 1211-19-4 | Molecular Weight | 212.24700 | |
| Density | 1.218g/cm3 | Boiling Point | 413.3ºC at 760 mmHg | |
| Molecular Formula | C13H12N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 203.8ºC | |
Use of SIRT-IN-3SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1]. |
| Name | 2-anilinobenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1]. |
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| Related Catalog | |
| In Vitro | SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells[1]. |
| References |
[1]. Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1(10):1059-62. |
| Density | 1.218g/cm3 |
|---|---|
| Boiling Point | 413.3ºC at 760 mmHg |
| Molecular Formula | C13H12N2O |
| Molecular Weight | 212.24700 |
| Flash Point | 203.8ºC |
| Exact Mass | 212.09500 |
| PSA | 55.12000 |
| LogP | 3.30240 |
| Vapour Pressure | 4.84E-07mmHg at 25°C |
| Index of Refraction | 1.663 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2924299090 |
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~80%
SIRT-IN-3 CAS#:1211-19-4 |
| Literature: Huang, Xiaohua; Anderson, Kevin W.; Zim, Danilo; Jiang, Lei; Klapars, Artis; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6653 - 6655 |
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~0%
SIRT-IN-3 CAS#:1211-19-4 |
| Literature: Huang, Xiaohua; Anderson, Kevin W.; Zim, Danilo; Jiang, Lei; Klapars, Artis; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6653 - 6655 |
|
~58%
SIRT-IN-3 CAS#:1211-19-4 |
| Literature: Maruyama; Kawata; Ono; Nishizawa; Ito; Inoue Bioscience, biotechnology, and biochemistry, 2001 , vol. 65, # 8 p. 1761 - 1765 |
|
~%
SIRT-IN-3 CAS#:1211-19-4 |
| Literature: ROCHE DIAGNOSTICS GMBH; F. HOFFMANN-LA ROCHE AG Patent: WO2008/52742 A1, 2008 ; Location in patent: Page/Page column 17; Sheet 1 ; |
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~%
SIRT-IN-3 CAS#:1211-19-4 |
| Literature: Goodman; Arbiter; Powell Journal of the American Chemical Society, 1933 , vol. 55, p. 4294,4297, 4298 |
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~%
SIRT-IN-3 CAS#:1211-19-4 |
| Literature: Coyne,W.E.; Cusic,J.W. Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1208 - 1213 |
![1-PHENYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE structure](https://www.chemsrc.com/caspic/077/20877-86-5.png)
| Precursor 6 | |
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| DownStream 4 | |
CAS#:20877-84-3
CAS#:17583-00-5
CAS#:66478-79-3
CAS#:66491-84-7| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| N-phenyl-anthranilic acid amide |
| Benzamide,o-anilino |
| N-Phenyl-anthranilsaeure-amid |
| Anilinobenzamide |
| N-phenylanthranylamide |
| N-phenylanthranilamide |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: SIRT-IN-3
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: SIRT-IN-3
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Benzamide,2-(phenylamino)-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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