128700-97-0

128700-97-0 structure

Name: Gingerenone A
Chemical Name: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one
CAS Number: 128700-97-0
Molecular Formula: C₂₁H₂₄O₅
Molecular Weight: 356.41
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2018-09-26 18:32:01
Modify Date: 2025-08-23 17:15:43
Gingerenone A is a Nrf2-Gpx4 activator with anti-breast-cancer properties. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. Gingerenone A also alleviates ferroptosis in secondary liver injury (SLI) in dextran sodium sulfate (DSS)-induced colitis mice. Gingerenone A can be isolated from Zingiber officinale[1][2].

Name	(E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one
Synonyms	(E)-gingerenone A (E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-4-hepten-3-one Y7369 gingerenone-A 1,7-bis(4-hydroxy-3-methoxyphenyl)-hept-4-en-3-one

Description	Gingerenone A is a Nrf2-Gpx4 activator with anti-breast-cancer properties. Gingerenone A results a delayed G2/M in cancer cells, following oxidative stress and senescence responses. Gingerenone A also alleviates ferroptosis in secondary liver injury (SLI) in dextran sodium sulfate (DSS)-induced colitis mice. Gingerenone A can be isolated from Zingiber officinale[1][2].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology
Target	Nrf2-Gpx4[1]
References	[1]. Yu TJ, et al. Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. Antioxidants (Basel). 2022 Mar 19;11(3):587. [2]. Chen Y, et al. Gingerenone A Alleviates Ferroptosis in Secondary Liver Injury in Colitis Mice via Activating Nrf2-Gpx4 Signaling Pathway. J Agric Food Chem. 2022 Oct 5;70(39):12525-12534.