134978-99-7

134978-99-7 structure

Name: Amino-PEG3-CH2COOH
Chemical Name: 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetic acid
CAS Number: 134978-99-7
Molecular Formula: C₈H₁₇NO₅
Molecular Weight: 207.22400
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-10-13 10:54:11
Modify Date: 2025-08-25 13:28:35
Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetic acid
Synonyms	2-<2-<2-(aminoethoxy)ethoxy>ethoxy>acetic acid Acetic acid,[2-[2-(2-aminoethoxy)ethoxy]ethoxy] 11-amino-3,6,9-trioxaundecanoic acid

Description	Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562