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86520-52-7

86520-52-7 structure
86520-52-7 structure
  • Name: Azido-PEG3-alcohol
  • Chemical Name: 2-[2-(2-Azidoethoxy)ethoxy]ethanol
  • CAS Number: 86520-52-7
  • Molecular Formula: C6H13N3O3
  • Molecular Weight: 175.18600
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2019-02-02 19:10:16
  • Modify Date: 2024-01-11 17:01:11
  • Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Name 2-[2-(2-Azidoethoxy)ethoxy]ethanol
Synonyms 2-(2-(2-AZIDOETHOXY)ETHOXY)ETHANOL
N3-EEET-OH
8-azido-3,6-dioxa-1-octanol
1-Azido-8-hydroxy-3,6-dioxaoctane
Azido-PEG3
8-Azido-3,6-dioxaoctanol solution
azidotriethylene glycol
8-Azido-3,6-dioxaoctanol
8-azido-3,6-dioxaoctan-1-ol
Description Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.
Molecular Formula C6H13N3O3
Molecular Weight 175.18600
Flash Point -33℃
Exact Mass 175.09600
PSA 88.44000
Storage condition -20°C Freezer
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H315
Precautionary Statements P210
Hazard Codes F,Xi
Risk Phrases 11-38
Safety Phrases 16
RIDADR UN 2398 3 / PGII
WGK Germany 3
HS Code 2929909090
139115-89-2 structure

139115-89-2

~97%

86520-52-7 structure

86520-52-7
Literature: Uppal, Timsy; Bhupathiraju, N.V.S. Dinesh K.; Vicente, M. Graca H. Tetrahedron, 2013 , vol. 69, # 23 p. 4687 - 4693
5197-62-6 structure

5197-62-6

~99%

86520-52-7 structure

86520-52-7
Literature: Lam, Son N.; Acharya, Priyamvada; Wyatt, Richard; Kwong, Peter D.; Bewley, Carole A. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10113 - 10120
77544-68-4 structure

77544-68-4

~99%

86520-52-7 structure

86520-52-7
Literature: Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
112-27-6 structure

112-27-6

~%

86520-52-7 structure

86520-52-7
Literature: Canaria, Christie A.; Smith, Jeffrey O.; Yu; Fraser, Scott E.; Lansford, Rusty Tetrahedron Letters, 2005 , vol. 46, # 28 p. 4813 - 4816
133699-09-9 structure

133699-09-9

~%

86520-52-7 structure

86520-52-7
Literature: Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
146462-59-1 structure

146462-59-1

~%

86520-52-7 structure

86520-52-7
Literature: Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
52337-72-1 structure

52337-72-1

~%

86520-52-7 structure

86520-52-7
Literature: Hashimoto, Masaru; Liu, Ying; Fang, Kan; Li, Hong-Yu; Campiani, Giuseppe; Nakanishi, Koji Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 1181 - 1194
745048-13-9 structure

745048-13-9

~%

86520-52-7 structure

86520-52-7
Literature: Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
239115-47-0 structure

239115-47-0

~%

86520-52-7 structure

86520-52-7
Literature: Hashimoto, Masaru; Liu, Ying; Fang, Kan; Li, Hong-Yu; Campiani, Giuseppe; Nakanishi, Koji Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 1181 - 1194
HS Code 2929909090
Summary 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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title: CAS No. 86520-52-7 | Chemsrc address: https://m.chemsrc.com/en/baike/454262.html

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