Name | [(E)-(2-hexylcyclopentylidene)amino]thiourea |
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Synonyms |
2-Hexyl-1-cyclopentanone thiosemicarbazone 33M20 BLT1 Block lipid transport-1 MIT 9952-53
BLT1 Block lipid transport-1 2-hexyl-1-cyclopentanone thiosemicarbazone |
Description | BLT-1, a thiosemicarbazone copper chelator, is a selectively scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 has pro-inflammatory functions through neutrophil recruitment[1][2][3]. |
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Related Catalog | |
In Vitro | BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake in ldlA[mSR-BI] cells[1]. BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells[1]. BLT-1 can inhibit SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC50=0.057 µM) and liposomes (IC50=0.098 µM) [2]. |
References |
Density | 1.14±0.1 g/cm3 |
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Boiling Point | 359.6±25.0 °C |
Molecular Formula | C12H23N3S |
Molecular Weight | 241.39600 |
Exact Mass | 241.16100 |
PSA | 87.04000 |
LogP | 4.05770 |
Storage condition | 2-8°C |
Hazard Codes | Xi |
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RIDADR | NONH for all modes of transport |
HS Code | 2930909090 |
HS Code | 2930909090 |
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Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |