BLT-1
BLT-1 structure
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Common Name | BLT-1 | ||
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| CAS Number | 321673-30-7 | Molecular Weight | 241.39600 | |
| Density | 1.14±0.1 g/cm3 | Boiling Point | 359.6±25.0 °C | |
| Molecular Formula | C12H23N3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of BLT-1BLT-1, a thiosemicarbazone copper chelator, is a selectively scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 has pro-inflammatory functions through neutrophil recruitment[1][2][3]. |
| Name | [(E)-(2-hexylcyclopentylidene)amino]thiourea |
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| Synonym | More Synonyms |
| Description | BLT-1, a thiosemicarbazone copper chelator, is a selectively scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 has pro-inflammatory functions through neutrophil recruitment[1][2][3]. |
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| Related Catalog | |
| In Vitro | BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake in ldlA[mSR-BI] cells[1]. BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells[1]. BLT-1 can inhibit SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC50=0.057 µM) and liposomes (IC50=0.098 µM) [2]. |
| References |
| Density | 1.14±0.1 g/cm3 |
|---|---|
| Boiling Point | 359.6±25.0 °C |
| Molecular Formula | C12H23N3S |
| Molecular Weight | 241.39600 |
| Exact Mass | 241.16100 |
| PSA | 87.04000 |
| LogP | 4.05770 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
| HS Code | 2930909090 |
| HS Code | 2930909090 |
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| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Intestinal scavenger receptors are involved in vitamin K1 absorption.
J. Biol. Chem. 289(44) , 30743-52, (2014) Vitamin K1 (phylloquinone) intestinal absorption is thought to be mediated by a carrier protein that still remains to be identified. Apical transport of vitamin K1 was examined using Caco-2 TC-7 cell ... |
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NOX2-derived ROS-mediated surface translocation of BLT1 is essential for exocytosis in human eosinophils induced by LTB4.
Int. Arch. Allergy Immunol. 165(1) , 40-51, (2014) Leukotriene B4 (LTB4) is a proinflammatory lipid mediator that elicits eosinophil exocytosis, leading to allergic inflammation. However, the detailed intracellular signaling mechanisms of eosinophil e... |
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Leukotriene B₄-leukotriene B₄ receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8⁺ T cells.
Immunology 146 , 50-8, (2015) Leukotriene B4 (LTB4 ) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells. Contact dermatitis is a common infla... |
| 2-Hexyl-1-cyclopentanone thiosemicarbazone 33M20 BLT1 Block lipid transport-1 MIT 9952-53 |
| BLT1 |
| Block lipid transport-1 |
| 2-hexyl-1-cyclopentanone thiosemicarbazone |