BLT-1

Modify Date: 2024-01-08 18:49:49

BLT-1 structure	Common Name	BLT-1
	CAS Number	321673-30-7	Molecular Weight	241.39600
	Density	1.14±0.1 g/cm3	Boiling Point	359.6±25.0 °C
	Molecular Formula	C₁₂H₂₃N₃S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of BLT-1

BLT-1, a thiosemicarbazone copper chelator, is a selectively scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 has pro-inflammatory functions through neutrophil recruitment[1][2][3].

Name	[(E)-(2-hexylcyclopentylidene)amino]thiourea
Synonym	More Synonyms

Description	BLT-1, a thiosemicarbazone copper chelator, is a selectively scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 has pro-inflammatory functions through neutrophil recruitment[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake in ldlA[mSR-BI] cells[1]. BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells[1]. BLT-1 can inhibit SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC50=0.057 µM) and liposomes (IC50=0.098 µM) [2].
References	[1]. Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15422-7. [2]. Nieland TJ, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47(1):460-72. [3]. Raldúa D, et al. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol Lett. 2007 Dec 10;175(1-3):1-7. Epub 2007 Aug 22.

Density	1.14±0.1 g/cm3
Boiling Point	359.6±25.0 °C
Molecular Formula	C₁₂H₂₃N₃S
Molecular Weight	241.39600
Exact Mass	241.16100
PSA	87.04000
LogP	4.05770
Storage condition	2-8°C

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2930909090

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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2-Hexyl-1-cyclopentanone thiosemicarbazone 33M20 BLT1 Block lipid transport-1 MIT 9952-53

BLT1

Block lipid transport-1

2-hexyl-1-cyclopentanone thiosemicarbazone