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  • DC Chemicals Limited
  • China
  • Product Name: DB04760
  • Price: $500.0/100mg $1000.0/250mg $2000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

Related CAS#:

544678-85-5

544678-85-5 structure
544678-85-5 structure
  • Name: DB04760
  • Chemical Name: pyrimidine-4,6-dicarboxylic acid bis-(4-fluoro-3-methyl-benzylamide)
  • CAS Number: 544678-85-5
  • Molecular Formula: C22H20F2N4O2
  • Molecular Weight: 410.41700
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
  • Create Date: 2018-12-18 12:01:24
  • Modify Date: 2024-01-11 09:01:27
  • DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2].

Name pyrimidine-4,6-dicarboxylic acid bis-(4-fluoro-3-methyl-benzylamide)
Synonyms MMP-13 INHIBITOR
N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide
Description DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC50 of 8 nM[1]. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity[2].
Related Catalog
Target

MMP-13:8 nM (IC50)

References

[1]. Engel CK, et al. Structural basis for the highly selective inhibition of MMP-13. Chem Biol. 2005 Feb;12(2):181-9.

[2]. Thomas S. Lisse, et al. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15): E2189–E2198.

Molecular Formula C22H20F2N4O2
Molecular Weight 410.41700
Exact Mass 410.15500
PSA 83.98000
LogP 4.01340