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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dropropizine
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17692-31-8

17692-31-8 structure

17692-31-8 structure

Name: Dropropizine
Chemical Name: 3-(4-phenylpiperazin-1-yl)propane-1,2-diol
CAS Number: 17692-31-8
Molecular Formula: C₁₃H₂₀N₂O₂
Molecular Weight: 236.310
Catalog: Pharmaceutical intermediate Heterocyclic compound Piperazine
Create Date: 2018-02-16 08:00:00
Modify Date: 2026-07-06 19:18:23
Dropropizine is a racemic non-opiate antitussive agent which has been used clinically for many years.

Name	3-(4-phenylpiperazin-1-yl)propane-1,2-diol
Synonyms	(±)-Dropropizine\|\|\|UCB-196\|\|\|UCB-1967 (+/-)-DROPROPIZINE UCB-196 Tussilex ribex 1-(2,3-Dihydroxypropyl)-4-phenylpiperazine EINECS 241-683-7 Dropropizine, 10 mM in DMSO lylin (-Dropropizine 1-Phenyl-4-(2,3-dihydroxypropyl)diethylenediamine Dipropizine MFCD00079124 (+-)-dropropizine katril UCB-1967 3-(4-Phenyl-1-piperazinyl)-1，2-pmpanediol DROPROPIZINE Dopropizin 1,2-PROPANEDIOL, 3-(4-PHENYL-1-PIPERAZINYL) 3-(4-phenyl-1-piperazinyl)propane-1,2-diol Catabex levodropropizine 3-(4-Phenyl-1-piperazinyl)-1,2-propanediol Katril gevotuss 3-(4-Phenyl-1-piperazinyl)1,2 ditustat dopropizin Dropropizine ISO 9001：2015 REACH (+-)-Dropropizine Ribex Larylin Ditustat 1-Phenyl-4-(2,3-dihydroxypropyl)piperazine 3-(4-phenyl-1-piperazinyl)-2-propanediol rac Dropropizine LABOTEST-BB LT00771927 tussilex catabex dipropizine 3-[4-PHENYL-1-PIPERAZINYL]-1,2-PROPANEDIOL

Description	Dropropizine is a racemic non-opiate antitussive agent which has been used clinically for many years.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology

Density	1.2±0.1 g/cm3
Boiling Point	412.7±34.0 °C at 760 mmHg
Melting Point	105-108ºC
Molecular Formula	C₁₃H₂₀N₂O₂
Molecular Weight	236.310
Flash Point	220.9±24.3 °C
Exact Mass	236.152481
PSA	46.94000
LogP	0.46
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.577

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ1074800

CHEMICAL NAME :: 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-

CAS REGISTRY NUMBER :: 17692-31-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H20-N2-O2

MOLECULAR WEIGHT :: 236.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TZ1074800
HS Code	2933599090

142730-57-2 structure

142730-57-2

~%

142730-59-4 structure

142730-59-4

142730-58-3 structure

142730-58-3

17692-31-8 structure

17692-31-8

Literature: Tetrahedron Letters, , vol. 33, # 22 p. 3231 - 3234

Precursor 1
142730-57-2
DownStream 0

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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