Dropropizine

Modify Date: 2024-01-02 13:29:58

Dropropizine Structure
Dropropizine structure
 Common Name Dropropizine
CAS Number 17692-31-8 Molecular Weight 236.310
Density 1.2±0.1 g/cm3 Boiling Point 412.7±34.0 °C at 760 mmHg
Molecular Formula C13H20N2O2 Melting Point 105-108ºC
MSDS Chinese USA Flash Point 220.9±24.3 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Dropropizine


Dropropizine is a racemic non-opiate antitussive agent which has been used clinically for many years.

 Names

Name 3-(4-phenylpiperazin-1-yl)propane-1,2-diol
Synonym More Synonyms

 Dropropizine Biological Activity

Description Dropropizine is a racemic non-opiate antitussive agent which has been used clinically for many years.
Related Catalog

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 412.7±34.0 °C at 760 mmHg
Melting Point 105-108ºC
Molecular Formula C13H20N2O2
Molecular Weight 236.310
Flash Point 220.9±24.3 °C
Exact Mass 236.152481
PSA 46.94000
LogP 0.46
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.577

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TZ1074800
CHEMICAL NAME :
1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-
CAS REGISTRY NUMBER :
17692-31-8
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C13-H20-N2-O2
MOLECULAR WEIGHT :
236.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3163649
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4372958

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TZ1074800
HS Code 2933599090

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles25

More Articles
Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough.

J. Int. Med. Res. 23(3) , 175-83, (1995)

The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for e...

Efficacy of levodropropizine in pediatric cough.

Pulm. Pharmacol. Ther. 25(5) , 337-42, (2012)

Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respir...

Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.

Ther. Drug Monit. 26(4) , 441-9, (2004)

Studies are described on the metabolism and the toxicologic analysis of the nonopioid cough suppressant dropropizine [R,S-3-(4-phenyl-1-piperazinyl)1,2-propandiol, DRO] in human urine using gas chroma...

 Synonyms

Dropropizine
1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-
Tussilex
1-(2,3-Dihydroxypropyl)-4-phenylpiperazine
(+-)-Dropropizine
Ribex
EINECS 241-683-7
Larylin
Ditustat
1-Phenyl-4-(2,3-dihydroxypropyl)piperazine
1-Phenyl-4-(2,3-dihydroxypropyl)diethylenediamine
Dipropizine
MFCD00079124
3-(4-phenylpiperazin-1-yl)propane-1,2-diol
Dopropizin
Catabex
levodropropizine
3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
Katril
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Related Compounds: More...
Levodropropizine
99291-24-4
Levodropropizine
99291-25-5
Chemsrc provides Dropropizine(CAS#:17692-31-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Dropropizine are included as well.>> amp version: Dropropizine

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