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80210-62-4

80210-62-4 structure
80210-62-4 structure
  • Name: cefpodoxime
  • Chemical Name: cefpodoxime
  • CAS Number: 80210-62-4
  • Molecular Formula: C15H17N5O6S2
  • Molecular Weight: 427.455
  • Catalog: API Antibiotics Cephalosporin
  • Create Date: 2018-04-17 08:00:00
  • Modify Date: 2024-01-03 12:08:51
  • Cefpodoxime (Cefpodoxime acid) is a potent antibiotic active against gram-positive and gram-negative bacteria. Cefpodoxime inhibits the majority of cells in microbial populations. Cefpodoxime can be used for acute otitis media, sinusitis and tosillopharyngitis research[1][2].

Name cefpodoxime
Synonyms (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-[(methyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Cefpodoxime Acid
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-3-(methoxymethyl)-8-oxo-, (6R,7R)-
(6R,7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefpodoxime
cefpodoxima
U 76253A
(6R-(6a,7b(Z)))-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
Cefpodoxime Proxetil EP Impurity A
Cefpodoxime Proxetil Impurity 1
Description Cefpodoxime (Cefpodoxime acid) is a potent antibiotic active against gram-positive and gram-negative bacteria. Cefpodoxime inhibits the majority of cells in microbial populations. Cefpodoxime can be used for acute otitis media, sinusitis and tosillopharyngitis research[1][2].
Related Catalog
In Vitro Cefpodoxime (Cefpodoxime acid) inhibits gram-negative anaerobic rods (Bacteroidaceae) with MIC values of 0.125-4 mg/L. Cefpodoxime inhibits Veillonella parvula with MIC values of 0.25-8 mg/L. Cefpodoxime inhibits Peptostreptococcus micros, Peptostreptococcus asaccharolyticus and Ruminococcus bromii with MIC values of <2 mg/L[1]. Cefpodoxime (Cefpodoxime acid) inhibits bacterial populations of S. pneumoniae and S. pyogenes. cfu[2].
In Vivo Cephalosporins (2.5-50 mg/kg; p.o.; every 8 hours; for 48 hours) have good curative effect in mice[3]. Animal Model: Female Swiss CD1 mice[3] Dosage: 2.5, 5, 10, 25, 40 and 50 mg/kg Administration: Oral administration; every 8 hours; for 48 hours Result: Efficacy was obtained with values of >350.
References

[1]. Werner H, et, al. Comparative in vitro activity of cefpodoxime against anaerobes other than Bacteroides fragilis. Infection. 1991 Sep-Oct;19(5):377-9.

[2]. Valentini S, et, al. In-vitro evaluation of cefpodoxime. J Antimicrob Chemother. 1994 Mar;33(3):495-508.

[3]. Pérez-Trallero E, et, al. Prediction of in-vivo efficacy by in-vitro early bactericidal activity with oral beta-lactams, in a dose-ranging immunocompetent mouse sepsis model, using strains of Streptococcus pneumoniae with decreasing susceptibilities to penicillin. J Chemother. 2001 Apr;13(2):118-25.

Density 1.8±0.1 g/cm3
Melting Point 200-202ºC
Molecular Formula C15H17N5O6S2
Molecular Weight 427.455
Exact Mass 427.062012
PSA 209.98000
LogP 0.94
Index of Refraction 1.780
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H317-H334
Precautionary Statements P261-P280-P342 + P311
Hazard Codes Xn
Risk Phrases 42/43
Safety Phrases 22-36/37-45
RIDADR NONH for all modes of transport

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80210-62-4 structure

80210-62-4

Literature: WO2011/77217 A1, ; Page/Page column 9 ;

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80210-62-4 structure

80210-62-4

Literature: WO2013/41999 A1, ;

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80210-62-4 structure

80210-62-4

Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 9 p. 2369 - 2374