957-68-6
957-68-6 structure
- Name: 7-Aminocephalosporanic acid
- Chemical Name: 7β-aminocephalosporanic acid
- CAS Number: 957-68-6
- Molecular Formula: C10H12N2O5S
- Molecular Weight: 272.278
- Catalog: API Antibiotics Cephalosporin
- Create Date: 2018-02-03 08:00:00
- Modify Date: 2026-07-02 14:37:04
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7-Aminocephalosporanic acid is the core chemical structure for the synthesis of cephalosporin antibiotics, is a potent β-lactamase inhibitor.
| Name | 7β-aminocephalosporanic acid |
|---|---|
| Synonyms |
(6R,7R)-3-(acetoxyMethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid
Cefazolin Impurity H 7-AMINO CEPHALOSPORIC ACID 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid Ceftazidime Impurity 25 7β-aminocephalosporanic acid zwitterion (6r,7s)-3-(acetyloxyMethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid 7-ACA 7-AMINOCHALOSPORANIC ACID 3-acetoxyMethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid 7-AMinochalsporanic acid 7-Amino 3-(Acetoxymethyl)-7β-aminocham-3-ene-4-cboxylic acid 7-Amino-3-acetoxymethyl-D3-chem-4-cboxylic acid 7-Amino-3-Methoxychalosporanic Acid（7-Amca） 7-Aminochalosporanic acid a potent β-lactamase inhibitor Ceftriaxone Impurity 18 (7R)-3-Acetyloxymethyl-7-aminocham-3-ene-4-cboxylic acid 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-cboxylic acid, 3-(acetyloxy)methyl-7-amino-8-oxo-, (6R,7R) Chalothin Impurity C（7-ACA） 7-Aminochalosporanic Acid > Cefazolin Sodium Impurity H (7-Aminochalosporanic Acid) Cefazolin Sodium Impurity H (7R)-7-Aminocephalosporanic acid EINECS 213-485-0 (7R)-7-AMinochalosporanic Acid (6R,7R)-7-Amino-3-[(acetyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid 3-Acetoxymethyl-7-aminoceph-3-em-4-oic Acid 7-AMinochalosporanic acid, R Cefalotin Impurity C Ceftriaxone IP Impurity E (6r,7s)-3-(acetyloxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid Cefazolin Impurity 1(Cefazolin Impurity H) Cefoperazone Impurity 5(Cefoperazone Impurity E) Cefradine impurity A 7-AMINOCHALOSPORIC ACID (7-ACA) 7-AMINOCHALOSPORANIC ACID (7-ACA) Aminochalosporanic 3-(AcetoxyMethyl)-7-aMinocheM -4-cboxylic Acid (6R,7R)-3-[(Acetyloxy)Methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic Acid (6R,TRANS)-3-[(ACETYLOXY)METHYL]-7-AMINO-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]-OCT-2-CBOXYLID ACID 7-Amino-3-acetoxymethylcham-3-ene-4-cboxylic acid 7-ACS 7-AMINO CHALOSPORIC ACID (6R,7R)-3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 7-Aminochalosporanic acid 7-Aminochalsporanic acid 7-Amino-3-(acetoxymethyl)cham-3-ene-4-cboxylic acid MFCD00005177 7-Amino-3-acetoxymethyl-3-chem-4-cboxylic acid 3-[(Acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid 7-Aminocephalsporanic acid phMaceautical interMediate 7-ACA Cefuroxime Impurity 25 7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Acetate Ester 7-ACA (7-AMINOCHALOSPORANIC ACID) Cefoperazone Impurity E 7-ACA Impurity (6R,7R)-3-(acetyloxymethyl)-7-ammonio-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylate 7beta-aminocephalosporanic acid 7b-Amino-3-acetoxymethylchemcboxylic acid (6R,7R)-3-[(Acetyloxy)methyl]-7-ami 7-Aminochalosporanicacid 7-Aminocephalosporanicacid Chalosporin Intermediate: 7-Aminochalosporanic Acid 7-Aminochalosporanic acid, Antibiotic for Culture Media Use Only (6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 7beta-aminochalosporanic acid 7-Aminochalosporanic acid, (dry wt.), may cont. up to water Cefazolin Impurity 1 |
| Description | 7-Aminocephalosporanic acid is the core chemical structure for the synthesis of cephalosporin antibiotics, is a potent β-lactamase inhibitor. |
|---|---|
| Related Catalog |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 560.6±50.0 °C at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C10H12N2O5S |
| Molecular Weight | 272.278 |
| Flash Point | 292.9±30.1 °C |
| Exact Mass | 272.046692 |
| PSA | 135.23000 |
| LogP | -0.80 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.661 |
| Storage condition | 2-8°C |
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H334 |
| Precautionary Statements | P261-P280-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn,Xi |
| Risk Phrases | R42/43:May cause sensitization by inhalation and skin contact . R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . |
| Safety Phrases | S22-S36/37-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2934996000 |
|
~80%
957-68-6 |
| Literature: Advanced Synthesis and Catalysis, , vol. 347, # 14 p. 1804 - 1810 |
|
~94%
957-68-6 |
| Literature: Fernandez-Lafuente, Roberto; Guisan, Jose M.; Pregnolato, Massimo; Terreni, Marco Tetrahedron Letters, 1997 , vol. 38, # 26 p. 4693 - 4696 |
|
~%
957-68-6 |
| Literature: Advanced Synthesis and Catalysis, , vol. 347, # 14 p. 1804 - 1810 |
|
~%
957-68-6 |
| Literature: Advanced Synthesis and Catalysis, , vol. 347, # 14 p. 1804 - 1810 |
|
~%
957-68-6 |
| Literature: Advanced Synthesis and Catalysis, , vol. 350, # 2 p. 343 - 348 |
|
~%
957-68-6 |
| Literature: Advanced Synthesis and Catalysis, , vol. 345, # 6-7 p. 783 - 789 |
|
~84%
957-68-6 |
| Literature: Kametani; Sekine; Honda Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 12 p. 4545 - 4547 |
|
~%
957-68-6 |
| Literature: Advanced Synthesis and Catalysis, , vol. 350, # 2 p. 343 - 348 |
|
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| Literature: Journal of Molecular Catalysis B: Enzymatic, , vol. 76, p. 52 - 58 |
| Precursor 5 | |
|---|---|
| DownStream 9 | |
![sodium,(6R,7R)-3-(acetyloxymethyl)-7-[[1-(4-bromophenyl)cyclopentanecarbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate structure](https://image.chemsrc.com/caspic/384/143433-72-1.png)
![sodium,(6R,7R)-3-(acetyloxymethyl)-7-[[1-(3-chlorophenyl)cyclopentanecarbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate structure](https://image.chemsrc.com/caspic/089/143407-76-5.png)
![sodium,(6R,7R)-3-(acetyloxymethyl)-7-[[1-(2-chlorophenyl)cyclopentanecarbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate structure](https://image.chemsrc.com/caspic/346/143433-73-2.png)
![3-(acetyloxymethyl)-8-oxo-7-[(2-pyridin-2-ylsulfanylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid structure](https://image.chemsrc.com/caspic/074/21593-22-6.png)
| HS Code | 2934996000 |
|---|---|
| Summary | 2934996000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.0%. General tariff:20.0% |