532-48-9

532-48-9 structure

Name: Euparin
Chemical Name: 1-(6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl)ethanone
CAS Number: 532-48-9
Molecular Formula: C₁₃H₁₂O₃
Molecular Weight: 216.23300
Catalog: Natural product Phenols
Create Date: 2018-05-18 08:00:00
Modify Date: 2024-01-04 00:41:05
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2].

Name	1-(6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl)ethanone
Synonyms	1-(6-Hydroxy-2-isopropenyl-benzofuran-5-yl)-aethanon 5-acetyl-6-hydroxy-2-isopropenylbenzofuran 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone 1-[6-hydroxy-2-(1-methylethenyl)-5-benzofuranyl]-ethanone Euparin 1-(6-hydroxy-2-isopropenyl-benzofuran-5-yl)-ethanone

Description	Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Neurological Disease
In Vitro	In Vero cells, Euparin shows antiviral activity against poliovirus types 1, 2, and 3 with EC50 values of 0.47 µg/mL, 0.12 µg/mL, and 0.15 µg/mL, respectively[1].
In Vivo	Euparin (8, 16 and 32 mg/kg) reduces depression-like behavior in Chronic Unpredictable Mild Stress (CUMS) model of mice. All doses of Euparin are found to increase the contents of monoamine neurotransmitter and decrease monoamine oxidase and reactive oxygen species (ROS) levels in brain of depression mice. Euparin restores CUMS-induced decrease of Spermidine/Spermine N1-Acetyltransferase 1 (SAT1), N-methyl-D-aspartate receptor subtype 2B (NMDAR2B) and brain derived neurotrophic factor (BDNF) expression[2].
References	[1]. aría Florencia Visintini Jaime, et al. Antipoliovirus Activity of the Organic Extract of Eupatorium buniifolium: Isolation of Euparin as an Active Compound. Evid Based Complement Alternat Med. 2013;2013:402364. [2]. Xu-Meng Han, et al. Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1/NMDAR2B/BDNF Signal Pathway. Biol Pharm Bull. 2020 Oct 1;43(10):1490-1500.

Density	1.187g/cm3
Boiling Point	258.3ºC at 760mmHg
Melting Point	152-153℃
Molecular Formula	C₁₃H₁₂O₃
Molecular Weight	216.23300
Flash Point	110ºC
Exact Mass	216.07900
PSA	50.44000
LogP	3.37410
Index of Refraction	1.602

Hazard Codes	Xi
HS Code	2932999099

173992-05-7

~83%

532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111

89-84-9

532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111

22877-01-6

532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111

62069-33-4

532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111

173992-03-5

532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111

173992-04-6

532-48-9

Literature: Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111

62069-34-5

532-48-9

Literature: Scannell, Ralph T.; Stevenson, Robert Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2927 - 2932

62069-33-4

56964-06-8

~32%

532-48-9

Literature: Scannell, Ralph T.; Stevenson, Robert Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2927 - 2932

Precursor 6
89-84-9 22877-01-6 62069-33-4 173992-03-5
62069-34-5 56964-06-8
DownStream 1
34293-13-5

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

532-48-9	6938-22-3
53947-86-7	34293-13-5
69309-25-7