Top Suppliers:I want be here
Related CAS#:
1805256-77-2 1804934-18-6
1805126-77-5 1803425-50-4
1805120-50-6 1806883-61-3
1283851-22-8 1805892-25-4
1803857-69-3 1805125-46-5

34140-59-5

34140-59-5 structure
34140-59-5 structure
  • Name: Trimebutine Maleate
  • Chemical Name: Trimebutine Maleate Salt
  • CAS Number: 34140-59-5
  • Molecular Formula: C26H33NO9
  • Molecular Weight: 503.54
  • Catalog: API Anesthetic Agents Skeletal muscle relaxant
  • Create Date: 2018-09-23 13:27:55
  • Modify Date: 2026-06-30 19:10:59
  • Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3].
Name Trimebutine Maleate Salt
Synonyms Sakion
3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester,Trimebutine maleate salt
(4a,5a,17b)-4,5-Epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
2a-Cyano-4a,5a-epoxyandrostan-17b-ol-3-one
Foldox
TriMebutine Maleate Salt, JP
TRIMEBUTINE MALEATE JPC93
EINECS 251-845-9
Trimebutine maleateQ: What is Trimebutine maleate Q: What is the CAS Number of Trimebutine maleate Q: What is the storage condition of Trimebutine maleate Q: What e the applications of Trimebutine maleate
eate saL
Trimedat
DIMETHYLAMINO-2-PHENYL-2-N-BUTYL-3,4,5-TRIMETHOXYBENZOATEMALEATE(TRIMEBUTINEMALEATE)
(1-Ethyl-1-phenyl-2-(3,4,5-trimethoxybenzoyloxy)ethyl)dimethylammonium hydrogen maleate
2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL 3,4,5-TRIMETHOXYBENZOATE MALEATE
Spabucol
Trimebutine-d3 maleate
3,4,5-trimethoxy-benzoicacibeta-(dimethylamino)-beta-ethylphenethylester
3,4,5-trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester maleate
Benzoic acid, 3,4,5-trimethoxy-, β-(dimethylamino)-β-ethylphenethyl ester, maleate (1:1)
MFCD00133874
MODRASTANE
TRIMEBUTINE MALEATE,2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL3.4.5-TRIMETHOXYBENZOATE MALEATE
Tretinoin acid
TRIMEBUTINE MALEAT
Transacalm
Cerekinon
TRIMEBUTIONE MALEATE
trimebutine malate
Trimebutin maleate
3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester
TRIMEBUTINE MALEATE SALT
3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester maleate salt
Recutin
Digerent
TRIMEBUTINE MALEATE
D5-Trimebutine Fumate
UNII:2A051GM4YM
Qumei Butin Maleate
2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate maleate
Polybutin
2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate (2Z)-2-butenedioate (1:1)
[1-ethyl-1-phenyl-2-(3,4,5-trimethoxybenzoyloxy)ethyl]dimethylammonium hydrogen maleate
Desopan
jp15 API
Trilostane
Trimebutine Maleatine
Modrenal
Salnatin
Trimebutine Maleate with Competitive Price CAS: 34-5
2-(dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate maleate
Selumito
Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester, (2Z)-2-butenedioate (1:1)
TM 906 {Maleate}
Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester, (Z)-2-butenedioate (1:1)
2-Dimethylamino-2-Phenyl-n-Butanol
Trimebutine Base/Maleate
Trimebutine maleate //BP
3,4,5-trimethoxy-benzoic acid beta-(dimethylamino)-beta-ethylphenethyl ester
debridat
Supeslone
Polibutin
Maleate trimebutine
Benzoic acid, 3,4,5-trimethoxy-, b-(dimethylamino)-b-ethylphenethyl ester maleate (1:1) (8CI)
Trimebutine maleate CRS
Trimebutine Maleate Jp
Debridat
2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate (2Z)-but-2-enedioate (1:1)
dromostat
(4α,5α,17β)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
Trimebutine Maleste
Modrefen
tm906
Vetoryl
Trimebutine maleate, 10 mM in DMSO
4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile
Trimebutine maL
Modulon
Transacal
Trimebutine (maleate)
3,4,5-TRIMETHOXYBENZOIC ACID 2-(DIMETHYLAMINO)-2-PHENYLBUTYL ESTER MALEATE SALT
Description Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3].
Related Catalog
References

[1]. Kaneto, H., M. Takahashi, and J. Watanabe, The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. J Pharmacobiodyn, 1990. 13(7): p. 448-53.

[2]. Roman, F.J., et al., Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther, 1999. 289(3): p. 1391-7.

[3]. Hiyama, T., et al., Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol, 2009. 24(4): p. 537-46.
Density 1.3±0.1 g/cm3
Boiling Point 497.8±45.0 °C at 760 mmHg
Melting Point 122-124ºC
Molecular Formula C26H33NO9
Molecular Weight 503.54
Flash Point 254.8±28.7 °C
PSA 131.83000
LogP 3.61
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.610
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DI0360000
CAS REGISTRY NUMBER :
34140-59-5
LAST UPDATED :
199507
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C22-H29-N-O5.C4-H4-O4
MOLECULAR WEIGHT :
503.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
365 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,688,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3610 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,688,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 15,688,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
47800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,752,1990 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5500 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,633,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
625 mg/kg
SEX/DURATION :
female 17-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,633,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3250 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,633,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6500 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,633,1982
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes C
Risk Phrases R34
Safety Phrases 26-27-36/37/39-45
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS DI0360000
HS Code 2922199090
HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:34140-59-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 34140-59-5 | Chemsrc address: https://m.chemsrc.com/en/baike/894561.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2026 ChemSrc All Rights Reserved