3520-14-7

3520-14-7 structure

Name: D-Tetrahydropalmatine
Chemical Name: D-Tetrahydropalmatine
CAS Number: 3520-14-7
Molecular Formula: C₂₁H₂₅NO₄
Molecular Weight: 355.427
Catalog: Natural product Alkaloid
Create Date: 2018-06-15 13:10:55
Modify Date: 2025-08-26 19:00:06
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis[1]. D-Tetrahydropalmatine is a Dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors[2]. D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor[3].

Name	D-Tetrahydropalmatine
Synonyms	6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)- levo-tetrahydropalmatine 6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aR)- (S)-tetrahydropalmatine (13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline Tetrahydropalmatine (+)-Tetrahydropalmatine (13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline d-Tetrahydropalmatine l-Tetrahydropalmatine (-)-Tetrahydropalmatine (R)-(+)-tetrahydropalmatine D-Tetrahydropalmatin (13aR)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline

Description	D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis[1]. D-Tetrahydropalmatine is a Dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors[2]. D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor[3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Metabolic Disease
Target	DA[2], OCT1[3]
References	[1]. Ma ZJ, et al. [Effects of different types and standard of processing vinegaron inherent constituents in rhizoma of Corydalis yanhusuo]. Zhongguo Zhong Yao Za Zhi. 2006 Mar;31(6):465-7. [2]. Xu SX, et al. Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain. Zhongguo Yao Li Xue Bao. 1989 Mar;10(2):104-10. [3]. Tu M, et al. Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important rolein its hepatotoxicity. Toxicology. 2013 Sep 15;311(3):225-30.

Hazard Codes	Xi

870282-72-7

483-14-7

3520-14-7

Literature: Journal of Organic Chemistry, , vol. 70, # 23 p. 9486 - 9494