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123653-11-2

123653-11-2 structure
123653-11-2 structure
  • Name: NS-398
  • Chemical Name: NS398
  • CAS Number: 123653-11-2
  • Molecular Formula: C13H18N2O5S
  • Molecular Weight: 314.357
  • Catalog: Biochemical Peptide
  • Create Date: 2018-11-24 06:36:09
  • Modify Date: 2025-08-23 18:16:51
  • NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
Name NS398
Synonyms MFCD00882995
Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]-
N-(2-Cyclohexyloxy-4-nitro-phenyl)-; methanesulfonamide
NS-398
Potassium Chloride
N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
Description NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
Related Catalog
Target

COX-2:3.8 μM (IC50)

In Vitro NS-398 is a non-steroidal an-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM[1]. NS-398 weakly inhibits PG endoperoxide synthase activity from sheep seminal vesicle microsomes (IC50, 11 μM)[2].
In Vivo NS-398 (0.5-10 mg/kg, p.o.) dose-dependently inhibits paw edema in rats, with an ED30 of 1.14 mg/kg, shows therapeutic effects on adjuvant arthritis (ED30, 4.69 mg/kg), exhibits dose-dependent analgesic activity (ED50, 1.65 mg/kg), and has antipyretic effect (ED50, 1.84 mg/kg) in rats. In mice, NS-398 suppresses writhing reactions induced by acetic acid with an ED50 of 8.2 mg/kg[2].
Animal Admin Mice[2] Briefly, male ddy mice weighing about 30 g are used. The writhing syndrome is induced by injecting 0.75% of acetic acid, intraperitoneally. Ten minutes later, the number of writhings are counted for the next 10 min. NS-398 is administered orally 30 min prior to the injection. The analgesic effect is expressed as % of inhibition, compared with the vehicle-treated control[2]. Rats[2] Briefly, male Lewis rats weighing about 160 g are used. Arthritis is induced by injecting 0.1 mL of 0.7% Mycobacterium tubercu-losis-liquid paraffin into the left hind paw. On day 15, the rats are grouped according to the degree of secondary lesions in the right hind paw. NS-398 is administered orally once daily from days 15 to 18. Foot volume is measured on day 19. Relative edema volume (REV) is calculated for each animal[2].
References

[1]. Futaki N, et al. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994 Jan;47(1):55-9.

[2]. Futaki N, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol. 1993 Jan;24(1):105-10.
Density 1.4±0.1 g/cm3
Boiling Point 490.6±55.0 °C at 760 mmHg
Melting Point 139 °C
Molecular Formula C13H18N2O5S
Molecular Weight 314.357
Flash Point 250.5±31.5 °C
Exact Mass 314.093628
PSA 109.60000
LogP 3.67
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.593
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 3824909990
HS Code 3824909990
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