Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one,4,6,7,14-tetrahydro-5-methyl-, hydrochloride (1:1)
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Purity: 98.0%
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6164-47-2

6164-47-2 structure

Name: protopine hydrochloride
Chemical Name: protopine hydrochloride
CAS Number: 6164-47-2
Molecular Formula: C₂₀H₂₀ClNO₅
Molecular Weight: 389.83
Catalog: Natural product Alkaloid
Create Date: 2018-08-05 01:33:22
Modify Date: 2024-01-14 19:36:03
Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity[1][2].

Name	protopine hydrochloride
Synonyms	Bis(1,3)benzodioxolo(4,5-C:5',6'-g)azecin-13(5H)-one,4,6,7,14-tetrahydro-5-methyl-,hydrochloride MFCD00236406 EINECS 228-196-5 Protopine HCl 7,13a-Secoberbin-13a-one,7-methyl-2,3:9,10-bis(methylenedioxy)-,hydrochloride Protopine,hydrochloride

Description	Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr;65(3):218-21. [2]. Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27;21(1):396.

WISWESSER LINE NOTATION :: T I5 G6 B-10-65 DN JO LO PV VO A&O KH WH&&T&&J D1 &GH

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,253,1952

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	25
Safety Phrases	36/37/39-45
RIDADR	UN 1544
RTECS	UL2000000
Packaging Group	III
Hazard Class	6.1(b)