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Related CAS#:
1665-48-1 1189944-95-3
1192812-66-0

1665-48-1

1665-48-1 structure
1665-48-1 structure
  • Name: Metaxalone
  • Chemical Name: Metaxalone
  • CAS Number: 1665-48-1
  • Molecular Formula: C12H15NO3
  • Molecular Weight: 221.252
  • Catalog: API Anesthetic Agents Skeletal muscle relaxant
  • Create Date: 2018-03-11 08:00:00
  • Modify Date: 2024-01-02 20:38:24
  • Metaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.Target: OthersMetaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.
Name Metaxalone
Synonyms 5-{[(3,5-dimethylphenyl)oxy]methyl}-1,3-oxazolidin-2-one
5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one
Metaxalone
5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone
2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-
Metaxolone
MFCD00867700
5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone
Skelaxin
EINECS 216-777-6
Description Metaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.Target: OthersMetaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.
Related Catalog
References

[1]. http://en.wikipedia.org/wiki/Metaxalone
Density 1.1±0.1 g/cm3
Boiling Point 453.6±14.0 °C at 760 mmHg
Melting Point 121-123ºC
Molecular Formula C12H15NO3
Molecular Weight 221.252
Flash Point 228.2±20.1 °C
Exact Mass 221.105194
PSA 47.56000
LogP 2.42
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.525
Storage condition -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RQ3850000
CHEMICAL NAME :
2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-
CAS REGISTRY NUMBER :
1665-48-1
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H15-N-O3
MOLECULAR WEIGHT :
221.28
WISWESSER LINE NOTATION :
T5MVOTJ D1OR C1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
775 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
515 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1690 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - rigidity (including catalepsy) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,326,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
490 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes F,T
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases 7-16-36/37-45
RIDADR NONH for all modes of transport
RTECS RQ3850000
105-67-9 structure

105-67-9
2451-62-9 structure

2451-62-9

~97%

1665-48-1 structure

1665-48-1
Literature: Dabur Pharma Ltd. Patent: US2007/185177 A1, 2007 ; Location in patent: Page/Page column 8 ;
2451-62-9 structure

2451-62-9
108-68-9 structure

108-68-9

~78%

1665-48-1 structure

1665-48-1
Literature: Yung Shin Pharma Ind. Co., Ltd. Patent: US6562980 B1, 2003 ;
66766-07-2 structure

66766-07-2
598-55-0 structure

598-55-0

~92%

1665-48-1 structure

1665-48-1
Literature: BOEHRINGER INGELHEIM CHEMICALS, INC. Patent: WO2008/6096 A1, 2008 ; Location in patent: Page/Page column 2-4 ;
59365-66-1 structure

59365-66-1
57-13-6 structure

57-13-6

~16%

1665-48-1 structure

1665-48-1
Literature: AUSPEX PHARMACEUTICALS, INC. Patent: US2009/270469 A1, 2009 ; Location in patent: Page/Page column 28 ;
153756-95-7 structure

153756-95-7

~%

103-90-2 structure

103-90-2
1665-48-1 structure

1665-48-1
Literature: Journal of Medicinal Chemistry, , vol. 38, # 20 p. 3983 - 3994

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