Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Triglycidyl isocyanurate
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Triglycidyl isocyanurate
Price: ￥308.0/100g ￥1128.0/500g
Purity: 98.0%
Stocking Period: 2 Day
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DC Chemicals Limited
China
Product Name: Triglycidyl isocyanurate
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g ￥220.0/10ml
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3,5-Triglycidyl isocyanurate
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Purity: 98.0%
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Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2451-62-9
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

2451-62-9

2451-62-9 structure

Name: Triglycidyl isocyanurate
Chemical Name: 1,3,5-Triglycidyl isocyanurate
CAS Number: 2451-62-9
Molecular Formula: C₁₂H₁₅N₃O₆
Molecular Weight: 297.264
Catalog: Chemical reagent Organic reagent Cyanate ester / isocyanate
Create Date: 2018-03-07 08:00:00
Modify Date: 2024-01-01 21:56:06
Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2].

Name	1,3,5-Triglycidyl isocyanurate
Synonyms	XB 2615 tgt (RS,RS,SR)-1,3,5-Tris(2,3-epoxypropyl)-s-triazine-2,4,6(1H,3H,5H)-trione Teroxirone EINECS 219-514-3 TGIC 1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione,TGIC,Triglycidyl isocyanurate 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(oxiranylmethyl)- 1,3,5-Tris(2-oxiranylmethyl)-1,3,5-triazinane-2,4,6-trione Isocyanuric Acid Triglycidyl Ester T6NVNVNVJ A1- BT3OTJ& C1- BT3OTJ& E1- BT3OTJ 1,3,5-triglycidyl-s-triazinetrione MFCD00080670 araldite pt-810 triglycidyl Triglycidyl Isocyanurate TEPIC Tris(2,3-epoxypropyl) Isocyanurate TGIC,triglycidyl isocyanurate 1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione glycidylisocyanurate Isocyanuric Acid Tris(2,3-epoxypropyl) Ester

Description	Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Research Areas >> Inflammation/Immunology
In Vitro	Triglycidyl isocyanurate (0-30 μM; 48 hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1]. Triglycidyl isocyanurate (0-30 μM; 48 hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Cell Viability Assay[1] Cell Line: A549, H460 and H1299 cells Concentration: 0 μM; 5 μM; 10 μM; 30 μM Incubation Time: 48 hours Result: Inhibited tumor cells growth in soft agar. Western Blot Analysis[1] Cell Line: A549, H460 and H1299 cells Concentration: 0 μM; 5 μM; 10 μM; 30 μM Incubation Time: 48 hours Result: Inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres
In Vivo	Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice[2]. Animal Model: Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area[2] Dosage: 1.8 mg/kg and 3.6 mg/kg Administration: Subcutaneous injection; every 2–3 days for total seven times; 30 days Result: Inhibited the growth of xenograft tumors.
References	[1]. Yu-Ling Ni, et al. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chem Biol Interact. 2018 Aug 1;291:137-143 [2]. Seung-Hun Kim, et al. Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.Biomed Pharmacother. 2018 Mar;99:997-1008

Density	1.6±0.1 g/cm3
Boiling Point	501.1±15.0 °C at 760 mmHg
Melting Point	95-98°C
Molecular Formula	C₁₂H₁₅N₃O₆
Molecular Weight	297.264
Flash Point	256.9±20.4 °C
Exact Mass	297.096100
PSA	103.59000
LogP	-2.77
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.635
Water Solubility	<0.1 g/100 mL at 20 ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ1994900

CHEMICAL NAME :: s-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2,3-epoxypropyl)-

CAS REGISTRY NUMBER :: 2451-62-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H15-N3-O6

MOLECULAR WEIGHT :: 297.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1200 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990 *** REVIEWS *** ACGIH TLV-TWA 0.05 mg/m3 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997

Symbol	GHS05, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301 + H331-H317-H318-H340-H373-H412
Precautionary Statements	P201-P261-P273-P280-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R23/25;R41;R43;R48/22;R52/53
Safety Phrases	S53-S45-S61
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	XZ1994900
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933699090

Precursor 0
DownStream 2
101-05-3 1665-48-1

HS Code	2933699090
Summary	2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

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