85409-38-7
85409-38-7 structure
- Name: Rilmenidine phosphate
- Chemical Name: N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine,phosphoric acid
- CAS Number: 85409-38-7
- Molecular Formula: C10H19N2O5P
- Molecular Weight: 278.242
- Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
- Create Date: 2018-08-24 19:57:50
- Modify Date: 2024-01-02 09:23:33
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Rilmenidine phosphate, an antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate is also an alpha 2-adrenoceptor agonist. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].
| Name | N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine,phosphoric acid |
|---|---|
| Synonyms |
2-Oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-, phosphate (1:1)
N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine phosphate (1:1) Rilmenidine phosphate 2-Oxazolamine, 4,5-dihydro-N-(dicyclopropylmethyl)-, phosphate (1:1) S 3341-3 {Phosphate} Rilmenidine dihydrogen phosphate S 3341-3 EINECS 287-106-2 4,5-Dihydro-N-(dicyclopropylmethyl)-2-oxazolamine phosphate (1:1) Hyperium |
| Description | Rilmenidine phosphate, an antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate is also an alpha 2-adrenoceptor agonist. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3]. |
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| Related Catalog | |
| In Vitro | Rilmenidine phosphate (25-100 μM; 24 hours) inhibits K562 cell proliferation[2].Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors[3]. Cell Proliferation Assay[2] Cell Line: K562 cells Concentration: 25, 50, 100 μM Incubation Time: 24 hours Result: Dose-dependently inhibited K562 colony formation. |
| In Vivo | Rilmenidine phosphate-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age[4]. Rilmenidine phosphate decreases levels of mutant huntingtin[4]. |
| References |
[1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. [3]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. |
| Boiling Point | 609.1ºC at 760 mmHg |
|---|---|
| Molecular Formula | C10H19N2O5P |
| Molecular Weight | 278.242 |
| Flash Point | 322.1ºC |
| Exact Mass | 278.103149 |
| PSA | 121.19000 |
| LogP | 0.04870 |
| Storage condition | -20℃ |
| Water Solubility | Freely soluble in water, slightly soluble in alcohol, practically insoluble in methylene chloride. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2934999090 |
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| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |