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127-47-9

127-47-9 structure
127-47-9 structure
  • Name: Retinyl acetate
  • Chemical Name: retinyl acetate
  • CAS Number: 127-47-9
  • Molecular Formula: C22H32O2
  • Molecular Weight: 328.488
  • Catalog: API Vitamins and minerals Vitamin AD drugs
  • Create Date: 2018-05-23 08:00:00
  • Modify Date: 2024-01-02 19:23:52
  • Retinyl acetate is a natural form of vitamin A and has potential antineoplastic and chemo preventive activities.
Name retinyl acetate
Synonyms Retinol, acetate, all-trans-
all-trans-Retinyl acetate
Retinyl acetate, all-trans-
Vitamin A acetate (VAN)
all-trans-Vitamin A acetate
VITAMIN A1 ACETATE
Retinyl acetate
MFCD00019413
trans-Vitamin A acetate
Retinol acetate,Retinyl acetate,Vitamin A acetate
Retinol, acetate
Retinol acetate
Myvax
O-Acetylretinol
Vitamin A, acetate
EINECS 204-844-2
Myvak
Myvak (VAN)
Retinol, acetate, all-trans- (8CI)
Myvax (VAN)
Retinol, O-acetyl-
Vitamin A ester
VITAMIN A ACETATE
Retinol acetate (JP15)
all-trans-Retinol acetate
Description Retinyl acetate is a natural form of vitamin A and has potential antineoplastic and chemo preventive activities.
Related Catalog
References

[1]. Moon, Richard C, et al. Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea. Nature. 1977 Jun 16;267(5612):620-1.

Density 1.0±0.1 g/cm3
Boiling Point 440.5±14.0 °C at 760 mmHg
Melting Point 57-58 °C
Molecular Formula C22H32O2
Molecular Weight 328.488
Flash Point 124.8±18.5 °C
Exact Mass 328.240234
PSA 26.30000
LogP 7.39
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.532
Storage condition 2-8°C
Water Solubility soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VH6825000
CHEMICAL NAME :
Retinol, acetate
CAS REGISTRY NUMBER :
127-47-9
BEILSTEIN REFERENCE NO. :
1915439
LAST UPDATED :
199701
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C22-H32-O2
MOLECULAR WEIGHT :
328.54
WISWESSER LINE NOTATION :
L6UTJ A1 B1U1Y1&U2U1Y1&U2OV1 C1 C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
432 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6352 ku/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6347 mg/kg/21D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Blood - changes in platelet count Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2208 mg/kg/21D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
51800 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
95 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
480 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
310 mg/kg
SEX/DURATION :
female 10-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1377 mg/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1377 mg/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
826 mg/kg
SEX/DURATION :
female 12-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1205 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
310 mg/kg
SEX/DURATION :
female 9-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
100 umol/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 44,356,1987 *** REVIEWS *** TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB-275-754 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80572 No. of Facilities: 277 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 5119 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80572 No. of Facilities: 550 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 13296 (estimated) No. of Female Employees: 7092 (estimated)
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360-H413
Precautionary Statements P201-P308 + P313
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful
Risk Phrases R38;R63
Safety Phrases S36/37-S45
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS VH6825000
HS Code 2936210000
HS Code 2936210000

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title: CAS No. 127-47-9 | Chemsrc address: https://m.chemsrc.com/en/baike/895583.html

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