Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Retinyl acetate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Vitamin A Acetate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

127-47-9

127-47-9 structure

Name: Retinyl acetate
Chemical Name: retinyl acetate
CAS Number: 127-47-9
Molecular Formula: C₂₂H₃₂O₂
Molecular Weight: 328.488
Catalog: API Vitamins and minerals Vitamin AD drugs
Create Date: 2018-05-23 08:00:00
Modify Date: 2026-06-29 21:49:40
Retinyl acetate is a natural form of vitamin A and has potential antineoplastic and chemo preventive activities.

Name	retinyl acetate
Synonyms	TRANS-RETINYL ACETATE Retinal acetate All-trans-retinol acetate VITAMIN-A-ACETATE, STAB. DL-A-TOCOPHEROL ,CONC.(I.PEANUTOIL) VITAMINAACETATE,FEED,POWDER(1,000,0001U/G) VITAMIN A1 ACETATE trans-Vitamin A acetate Retinol, acetate Myvax VITAMIN A ACETATE(RETINOL ACETATE)(RG) 3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl) RETINOL ACETATE ALL TRANS Vitamin A, acetate VITAMIN A (ACETATE) MEETS TESTING S VITAMINAACETATE(1,700,0001U/G) Myvak VitaminAAcetateB.P.,U.S.P RETINOL ACETATE, 100MG, NEAT all-trans-Retinol Acetat VITAMINAACETATE(1,000,0001U/G) VITAMINAACETATE(2,000,0001U/G) Davitan A Retinol, acetate, all-trans- (8CI) VITAMINAACETATE(2,800,0001U/G) (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-,6,8-nonatetraen- 1-ol Acetate RETINOL ACETATE ALL TRANS CELLCULTURE T ESTED VITAMINAACETATE,FOOD,POWDER(500,0001U/G) Vitamin A acetate in gelatin, powder VITAMIN A ACETATE(RETINOL ACETATE)(AS) Vitamin A Acetate 1000 IU Feed ade 3,7-Dimethyl-9-(2,6,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol acetate Retinol acetate (JP15) Water Soluble Retinyl Acetate (Vitamin A Acetate), Liposomal Retinyl Acetate, Retinyl Acetate NanoEmusion ALL-TRANS-RETINYL ACETATE all-trans-Retinyl acetate VITAMINAACETATE,SYNTHETIC,CRYSTALLINE VitaMin A ace Retinol acetate Vitamin A acetate all-trans Vitamin A acetate all-trans-Retinyl acetate RETINOL ACETATE, WATER SOLUBLE Antixerophthalmic vitamin acetate Crystalets Vitamin A acetate (VAN) VITAMIN-A-ACETATE STAB. BHA/BHT CONC VitaminAAcetateForBiochemistry VITAMINAACETATE,FEED,POWDER(650,0001U/G) all-trans-Vitamin A acetate MFCD00019413 Retinol acetate,Retinyl acetate,Vitamin A acetate Retinol acetate RETINOL ACETATE ALL TRANS INSECT CELLCU LTURE TESTE VITAMIN A ACETATE, ALL TRANS O-Acetylretinol all-trans-Retinyl acetate, 1.5 million IU/g, in sunflower oil, /, stab EINECS 204-844-2 VITAMINAACETATE,FEED,POWDER(500,0001U/G) Retinyl acetate, 2750 IU/mg RETINOL ACETATE Vitamin A Acetate, all trans(Synthetic) 500,000 u/g TRANS-RETINOL ACETATE VITAMINAACETATE,FEED,POWDER(1,500,0001U/G) ALL-TRANS VITAMIN A ACETATE Myvak (VAN) Myvax (VAN) nona-2,4,6,8-tetraen-1-yl acetate (2E,4E,6E,8E) Retinyl (Retinol) Acetate VITAMINAACETATE(2,500,0001U/G) Vitamin A ester VITAMINAACETATE RETINYL ACETATE Retinyl acetate solution VITAMINAACETATE(1,500,0001U/G) VITAMIN A ACETATE Retinyl Acetate (Vitamin A Acetate) all-trans-Retinol acetate

Description	Retinyl acetate is a natural form of vitamin A and has potential antineoplastic and chemo preventive activities.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Others
References	[1]. Moon, Richard C, et al. Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea. Nature. 1977 Jun 16;267(5612):620-1.

Density	1.0±0.1 g/cm3
Boiling Point	440.5±14.0 °C at 760 mmHg
Melting Point	57-58 °C
Molecular Formula	C₂₂H₃₂O₂
Molecular Weight	328.488
Flash Point	124.8±18.5 °C
Exact Mass	328.240234
PSA	26.30000
LogP	7.39
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.532
Storage condition	2-8°C
Water Solubility	soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VH6825000

CHEMICAL NAME :: Retinol, acetate

CAS REGISTRY NUMBER :: 127-47-9

BEILSTEIN REFERENCE NO. :: 1915439

LAST UPDATED :: 199701

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C22-H32-O2

MOLECULAR WEIGHT :: 328.54

WISWESSER LINE NOTATION :: L6UTJ A1 B1U1Y1&U2U1Y1&U2OV1 C1 C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 432 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6352 ku/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6347 mg/kg/21D-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Blood - changes in platelet count Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2208 mg/kg/21D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 51800 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 95 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 480 mg/kg

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 310 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1377 mg/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - respiratory system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1377 mg/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 826 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1205 mg/kg

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 310 mg/kg

SEX/DURATION :: female 9-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 100 umol/L

REFERENCE :: ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 44,356,1987 *** REVIEWS *** TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB-275-754 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80572 No. of Facilities: 277 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 5119 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80572 No. of Facilities: 550 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 13296 (estimated) No. of Female Employees: 7092 (estimated)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360-H413
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful
Risk Phrases	R38;R63
Safety Phrases	S36/37-S45
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	VH6825000
HS Code	2936210000

Precursor 7
108-24-7 68-26-8 26586-02-7 59830-43-2
59830-46-5 128-37-0 103905-08-4
DownStream 9
472-86-6 116-31-4 514-85-2 7235-40-7
43219-55-2 70244-78-9 68-26-8 79-81-2
631-88-9

HS Code	2936210000

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