Retinyl acetate

Modify Date: 2026-06-29 21:49:40

Retinyl acetate Structure
Retinyl acetate structure
 Common Name Retinyl acetate
CAS Number 127-47-9 Molecular Weight 328.488
Density 1.0±0.1 g/cm3 Boiling Point 440.5±14.0 °C at 760 mmHg
Molecular Formula C22H32O2 Melting Point 57-58 °C
MSDS Chinese USA Flash Point 124.8±18.5 °C
Symbol GHS08
GHS08		 Signal Word Danger

 Use of Retinyl acetate


Retinyl acetate is a natural form of vitamin A and has potential antineoplastic and chemo preventive activities.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name retinyl acetate
Synonym More Synonyms

 Retinyl acetate Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Retinyl acetate is a natural form of vitamin A and has potential antineoplastic and chemo preventive activities.
Related Catalog
References

[1]. Moon, Richard C, et al. Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea. Nature. 1977 Jun 16;267(5612):620-1.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.0±0.1 g/cm3
Boiling Point 440.5±14.0 °C at 760 mmHg
Melting Point 57-58 °C
Molecular Formula C22H32O2
Molecular Weight 328.488
Flash Point 124.8±18.5 °C
Exact Mass 328.240234
PSA 26.30000
LogP 7.39
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.532
InChIKey QGNJRVVDBSJHIZ-QHLGVNSISA-N
SMILES CC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C
Storage condition 2-8°C
Water Solubility soluble

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VH6825000
CHEMICAL NAME :
Retinol, acetate
CAS REGISTRY NUMBER :
127-47-9
BEILSTEIN REFERENCE NO. :
1915439
LAST UPDATED :
199701
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C22-H32-O2
MOLECULAR WEIGHT :
328.54
WISWESSER LINE NOTATION :
L6UTJ A1 B1U1Y1&U2U1Y1&U2OV1 C1 C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
432 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6352 ku/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6347 mg/kg/21D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Blood - changes in platelet count Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2208 mg/kg/21D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
51800 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
95 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
480 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
310 mg/kg
SEX/DURATION :
female 10-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1377 mg/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1377 mg/kg
SEX/DURATION :
female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
826 mg/kg
SEX/DURATION :
female 12-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1205 mg/kg
SEX/DURATION :
female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
310 mg/kg
SEX/DURATION :
female 9-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
100 umol/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 44,356,1987 *** REVIEWS *** TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB-275-754 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80572 No. of Facilities: 277 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 5119 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80572 No. of Facilities: 550 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 13296 (estimated) No. of Female Employees: 7092 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360-H413
Precautionary Statements P201-P308 + P313
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful
Risk Phrases R38;R63
Safety Phrases S36/37-S45
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS VH6825000
HS Code 2936210000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2936210000

 Articles51

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Simultaneous analysis for water- and fat-soluble vitamins by a novel single chromatography technique unifying supercritical fluid chromatography and liquid chromatography.

J. Chromatogr. A. 1362 , 270-7, (2014)

Chromatography techniques usually use a single state in the mobile phase, such as liquid, gas, or supercritical fluid. Chromatographers manage one of these techniques for their purpose but are sometim...

Effects of microbial phytase on apparent and standardized total tract digestibility of calcium in calcium supplements fed to growing pigs.

J. Anim. Sci. 93 , 2255-64, (2015)

An experiment was conducted to test the hypothesis that differences in the apparent total tract digestibility (ATTD) and standardized total tract digestibility (STTD) of Ca exist among Ca supplements ...

Ultra-performance liquid chromatographic determination of tocopherols and retinol in human plasma.

J. Chromatogr. Sci. 52(9) , 1065-70, (2014)

A rapid, selective and sensitive ultra-performance liquid chromatography method has been developed for the detection and quantification of tocopherols and retinol in human plasma. Alpha-tocopherol, ga...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

all-trans-Retinyl acetate
Vitamin A acetate (VAN)
all-trans-Vitamin A acetate
VITAMIN A1 ACETATE
Retinyl acetate
MFCD00019413
trans-Vitamin A acetate
Retinol acetate,Retinyl acetate,Vitamin A acetate
Retinol, acetate
Retinol acetate
Myvax
O-Acetylretinol
Vitamin A, acetate
EINECS 204-844-2
Myvak
Myvak (VAN)
Retinol, acetate, all-trans- (8CI)
Myvax (VAN)
Vitamin A ester
VITAMIN A ACETATE
Retinol acetate (JP15)
all-trans-Retinol acetate

 Retinyl acetate | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of retinyl acetate?
A: SMILES notation of retinyl acetate is CC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C.
Q: What is the English name of retinyl acetate?
A: The English name of retinyl acetate is retinyl acetate.
Q: What is the molecular formula of retinyl acetate?
A: Molecular formula of retinyl acetate is C22H32O2.
Q: What is the polar surface area (PSA) of retinyl acetate?
A: Polar surface area (PSA) of retinyl acetate is 26.30000.
Q: What is the melting point of retinyl acetate?
A: Melting point of retinyl acetate is 57-58 °C.
Q: How is the water solubility of retinyl acetate?
A: Water solubility of retinyl acetate: soluble.
Q: What is the safety information for retinyl acetate?
A: Safety information for retinyl acetate: S36/37-S45.
Q: What is the boiling point of retinyl acetate?
A: Boiling point of retinyl acetate is 440.5±14.0 °C at 760 mmHg.
Q: What are the uses of retinyl acetate?
A: Main uses of retinyl acetate: Retinyl acetate is a natural form of vitamin A and has potential antineoplastic and chemo preventive activities.
Q: What is the LogP of retinyl acetate?
A: LogP of retinyl acetate is 7.39.

 Retinyl acetatefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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