Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: (20S)-Protopanaxatriol
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PROTOPANAXTRIOL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

naturewill
China
Product Name: (20S)-Protopanaxatriol
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Bella
Email: 3157321941@qq.com

34080-08-5

34080-08-5 structure

34080-08-5 structure

Name: (20S)-Protopanaxatriol
Chemical Name: protopanaxatriol
CAS Number: 34080-08-5
Molecular Formula: C₃₀H₅₂O₄
Molecular Weight: 476.73
Catalog: Natural product Moss
Create Date: 2018-04-08 08:00:00
Modify Date: 2026-07-01 17:03:10
(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor.

Name	protopanaxatriol
Synonyms	PROTOPANAXADIOL(RG) PROTOPANAXTRIOL Protopanaxtriol (3β,6α,12β,14β)-4,4,14-Trimethyl-18-norcholest-24-ene-3,6,12,20-tetrol Damm-24-ene-3,6,12,20-tetrol, (3beta,6alpha,12beta) (3b,6a,12b)-Damm-24-ene-3,6,12,20-tetrol Damm-24-ene-3,6,12,20-tetrol, (3β,6α,12β) (3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-((S)-2-Hydroxy-6-methylht-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol 20(S)-APPT Protopanaxatriol-RM (20S)-5α-Damm-24-ene-3β,6α,12β,20-tetrol (3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-[(2R)-2-hydroxy-6-methylht-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol Protopanaxatriol, 20S S-Protopanaxatriol (20S) Protopanaxatriol,Estrogen Rector/ERR,Glucocorticoid Rector,Apoptosis,(20S)-Protopanaxatriol,inhibit,Inhibitor,Liver X rector,LXR,(20S)Protopanaxatriol g-PPT 20(S)-APPT,g-PPT 20(S)-Protopanaxatriol 34-5 (20S)-Protopanaxatriol (~ HPLC) 20(S)-Protopanaxtriol(PPT) (20S)-Protopanaxatriol/PPT (2S)-Protopanaxatriol 20(S)-Protopanaxtriol 20S-Protopanaxatriol (20S)-Protopanaxatriol APPT

Description	(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor.
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Cardiovascular Disease Natural Products >> Steroids
Target	Glucocorticoid receptor, Oestrogen receptor[1], LXRα[2]
In Vitro	(20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs). (20S)-Protopanaxatriol (g-PPT) increases [Ca2+]i with an EC50 of 482 nM in HUVECs. (20S)-Protopanaxatriol (1 µM) elevates NO production via ERβ[1]. (20S)-Protopanaxatriol (PPT) inhibits the autonomous transactivation of Gal4-LXRα LBD, the T0901317-dependent transcription of SREBP-1c and its promoter. (20S)-Protopanaxatriol (10 μg/mL) blocks the recruitment of RNA polymerase II to the LXRE region of SREBP-1c. (20S)-Protopanaxatriol also inhibits T0901317-dependent transcription of LXRα target genes related to lipogenesis, and reduces T0901317-induced cellular triglyceride (TG) accumulation in primary hepatocytes, but does not alter transcription of ABCA1, also an LXRα target gene[2].
References	[1]. Leung KW, et al. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb;156(4):626-37. [2]. Oh GS, et al. 20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes. J Pharmacol Sci. 2015 Jun;128(2):71-7.

Density	1.1±0.1 g/cm3
Boiling Point	588.8±50.0 °C at 760 mmHg
Molecular Formula	C₃₀H₅₂O₄
Molecular Weight	476.73
Flash Point	242.9±24.7 °C
PSA	80.92000
LogP	5.41
Vapour Pressure	0.0±3.7 mmHg at 25°C
Index of Refraction	1.541
Storage condition	-20°C

RIDADR	NONH for all modes of transport

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.