1510-21-0

1510-21-0 structure

Name: 4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid
Chemical Name: Cholesteryl hemisuccinate
CAS Number: 1510-21-0
Molecular Formula: C₃₁H₅₀O₄
Molecular Weight: 486.73
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-25 08:26:34
Modify Date: 2024-01-02 04:14:12
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2].

Name	Cholesteryl hemisuccinate
Synonyms	4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid 3-cholesteryloxycarbonylpropanoic acid Cholesteryl hydrogen succinate EINECS 216-148-6 3-(3-cholesteryloxycarbonyl)propanoic acid MONO-CHOLESTERYL-SUCCINATE CHOLESTEROL HYDROGEN SUCCINATE 3β-Hydroxy-5-cholestene 3-hemisuccinate MFCD00037705 cholesteryl hemisuccinate free acid cholesterylsuccinate 5-Cholesten-3β-ol 3-hemisuccinate Succinic Acid Monocholesterol Ester 5-CHOLESTEN-3BETA-OL 3-HEMISUCCINATE Butanedioic acid, mono[(3β)-cholest-5-en-3-yl] ester

Description	Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vivo	Cholesteryl hemisuccinate（100 mg/kg；ip；AAP 前单次给药）消除 AAP（350-500 mg/kg；ip；单次给药）在 ICR 小鼠 (CD-1) 中诱导的细胞凋亡和坏死的组织学和生化诊断[1]。
References	[1]. Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279(3):1470-83. [2]. Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093.

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