4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid structure
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Common Name | 4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid | ||
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CAS Number | 1510-21-0 | Molecular Weight | 486.73 | |
Density | 1.1±0.1 g/cm3 | Boiling Point | 586.0±43.0 °C at 760 mmHg | |
Molecular Formula | C31H50O4 | Melting Point | 178 °C | |
MSDS | Chinese USA | Flash Point | 179.6±21.7 °C |
Use of 4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acidCholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2]. |
Name | Cholesteryl hemisuccinate |
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Synonym | More Synonyms |
Description | Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2]. |
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Related Catalog | |
In Vivo | Cholesteryl hemisuccinate(100 mg/kg;ip;AAP 前单次给药)消除 AAP(350-500 mg/kg;ip;单次给药)在 ICR 小鼠 (CD-1) 中诱导的细胞凋亡和坏死的组织学和生化诊断[1]。 |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 586.0±43.0 °C at 760 mmHg |
Melting Point | 178 °C |
Molecular Formula | C31H50O4 |
Molecular Weight | 486.73 |
Flash Point | 179.6±21.7 °C |
Exact Mass | 486.370911 |
PSA | 63.60000 |
LogP | 10.32 |
Vapour Pressure | 0.0±3.5 mmHg at 25°C |
Index of Refraction | 1.529 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.
Biochem. Biophys. Res. Commun. 456(1) , 116-21, (2014) G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melan... |
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Solution structure of the transmembrane 2 domain of the human melanocortin-4 receptor in sodium dodecyl sulfate (SDS) micelles and the functional implication of the D90N mutant.
Biochim. Biophys. Acta 1848 , 1294-302, (2015) The melanocortin receptors (MCRs) are members of the G protein-coupled receptor (GPCR) 1 superfamily with seven transmembrane (TM) domains. Among them, the melanocortin-4 receptor (MC4R) subtype has b... |
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Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter.
Nat. Commun. 6 , 6112, (2015) SWEET family proteins mediate sugar transport across biological membranes and play crucial roles in plants and animals. The SWEETs and their bacterial homologues, the SemiSWEETs, are related to the PQ... |
4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid |
3-cholesteryloxycarbonylpropanoic acid |
Cholesteryl hydrogen succinate |
EINECS 216-148-6 |
3-(3-cholesteryloxycarbonyl)propanoic acid |
MONO-CHOLESTERYL-SUCCINATE |
CHOLESTEROL HYDROGEN SUCCINATE |
3β-Hydroxy-5-cholestene 3-hemisuccinate |
MFCD00037705 |
cholesteryl hemisuccinate free acid |
cholesterylsuccinate |
5-Cholesten-3β-ol 3-hemisuccinate |
Succinic Acid Monocholesterol Ester |
5-CHOLESTEN-3BETA-OL 3-HEMISUCCINATE |
Butanedioic acid, mono[(3β)-cholest-5-en-3-yl] ester |