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145-13-1

145-13-1 structure

145-13-1 structure

Name: Pregnenolone
Chemical Name: pregnenolone
CAS Number: 145-13-1
Molecular Formula: C₂₁H₃₂O₂
Molecular Weight: 316.478
Catalog: Natural product Steroidal compound
Create Date: 2018-07-19 18:21:44
Modify Date: 2026-07-01 18:26:17
Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).

Name	pregnenolone
Synonyms	EINECS 205-647-4 prenolon pregnenolone solution,100ppm Pregnenolone 0 prenenolone Pregnenlolone Pregnenolone Micron 3β-Hydroxy-5-pregnen-20-one, Pregnenolone DELTA5-PREGNEN-3B-OL-20-ONE (3-beta)-pregn-5-en-20-on Pregnenolone> PREGNENOLONE 1-[(3S,8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-hydroxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 5-PREGNEN-3BETA-OL-20-ONE ZK-5553 1-((3S,8S,9S,10R,13S,14S,17S)-3-HYDROXY-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-ETHANONE Pregnenolone solution Pregnelone 3-beta-hydroxy-pregn-5-en-20-on 3-Hydroxypregn-5-en-20-one 3BETA-HYDROXYPREGN-5-EN-20-ONE 5-Pregnen-3β-ol-20-one 3β-Hydroxy-5-pregnen-20-one, 5-Pregnen-3β-ol-20-one 5-pregnen-3B-ol-20-one thenolone Progeserone 1-((3S,8S,9S,10R,13S,14S,17S)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone Pregnenolone 5-Pregnenolone MFCD00003628 nen-3β-oL 3Hydroxy-5-Pregnen-20-one fast-shipping Pregnenolone 3β-Hydroxypregn-5-en-20-one Pregnenolone, 10 mM in DMSO 4-(4-methylphenyl)-3,5-diphenyl-1,2,4-triazole Pregnenolone in Methanol 3β-hydroxy-pregn-5-ene-20-one Pregnenolone/Pregnenolone acetate 5-Preg Pregnenolone3beta-Hydroxy-5-pregnen-20-one 3β-Hydroxy-5-pregnen-20-one 3b-hydroxy-5-pregnen-20-one DELTA5-PREGNENOLONE DELTA-5-PREGNENE-3B-OL-20-ONE pregnolon DELTA5-PREGNEN-3BETA-OL-20-ONE 5-pregnen-3β-ol-20-one High quality Pregnenolone 20-one PREGNENOLONE(RG) 3BETA-HYDROXY-5-PREGNEN-20-ONE Pregnenolon : 3beta-Hydroxypregn-5-en-20-on 5-Pregnen-3β-oL (3β)-3-Hydroxypregn-5-en-20-one Pregn-5-en-20-one, 3-hydroxy-, (3β) 5-pregnenolone PREGNENOLONE(3BETA-HYDROXYPREGN-5-EN-20-ONE) PREGNENOLONE(P) Pregnenolone (3beta-Hydroxypregn-5 1-[(3S,8S,9S,10R,13S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Pregnenolone (3β-Hydroxypregn-5-en-20-one)

Description	Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Research Areas >> Neurological Disease Natural Products >> Steroids
Target	CB1 Receptor Human Endogenous Metabolite
In Vitro	The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1].
In Vivo	Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1].
Animal Admin	Mice and Rats[1] Adult male Wistar rats (weighing 320-340g), Sprague Dawley male rats (weighing 330-350g), C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30 g at the beginning of the experiments) are used. Pregnenolone is injected subcutaneously (sc). The injection volumes are 1 mL/kg of body weight for rats and 10 mL/kg for mice[1].
References	[1]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8.

Density	1.1±0.1 g/cm3
Boiling Point	443.3±45.0 °C at 760 mmHg
Melting Point	188-190 °C
Molecular Formula	C₂₁H₃₂O₂
Molecular Weight	316.478
Flash Point	188.9±21.3 °C
Exact Mass	316.240234
PSA	37.30000
LogP	4.52
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.550
Storage condition	2~8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5560700

CHEMICAL NAME :: Pregn-5-en-20-one, 3-beta-hydroxy-

CAS REGISTRY NUMBER :: 145-13-1

LAST UPDATED :: 199609

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H32-O2

MOLECULAR WEIGHT :: 316.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 35 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H312 + H332-H319
Precautionary Statements	P210-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU5560700
HS Code	2937290090

Precursor 8
1778-02-5 18843-28-2 979-02-2 136634-01-0
13057-17-5 73465-46-0 2722-98-7 1162-53-4
DownStream 10
566-78-9 387-79-1 53-43-0 521-17-5
1224-94-8 901-57-5 520-88-7 14148-09-5
1778-02-5 145-14-2

HS Code	2937290090

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