Pregnenolone

Modify Date: 2025-08-22 07:16:52

Pregnenolone structure	Common Name	Pregnenolone
	CAS Number	145-13-1	Molecular Weight	316.478
	Density	1.1±0.1 g/cm3	Boiling Point	443.3±45.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₃₂O₂	Melting Point	188-190 °C
	MSDS	Chinese USA	Flash Point	188.9±21.3 °C
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of Pregnenolone

Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).

Name	pregnenolone
Synonym	More Synonyms

Description	Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Research Areas >> Neurological Disease Natural Products >> Steroids
Target	CB1 Receptor Human Endogenous Metabolite
In Vitro	The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1].
In Vivo	Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1].
Animal Admin	Mice and Rats[1] Adult male Wistar rats (weighing 320-340g), Sprague Dawley male rats (weighing 330-350g), C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30 g at the beginning of the experiments) are used. Pregnenolone is injected subcutaneously (sc). The injection volumes are 1 mL/kg of body weight for rats and 10 mL/kg for mice[1].
References	[1]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8.

Density	1.1±0.1 g/cm3
Boiling Point	443.3±45.0 °C at 760 mmHg
Melting Point	188-190 °C
Molecular Formula	C₂₁H₃₂O₂
Molecular Weight	316.478
Flash Point	188.9±21.3 °C
Exact Mass	316.240234
PSA	37.30000
LogP	4.52
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.550
Storage condition	2~8℃

Pregnenolone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5560700

CHEMICAL NAME :: Pregn-5-en-20-one, 3-beta-hydroxy-

CAS REGISTRY NUMBER :: 145-13-1

LAST UPDATED :: 199609

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H32-O2

MOLECULAR WEIGHT :: 316.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 35 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H312 + H332-H319
Precautionary Statements	P210-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU5560700
HS Code	2937290090

Precursor 8
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CAS#:13057-17-5 Bromo(methoxy)m... CAS#:73465-46-0 Pregna-5,17(20)... CAS#:2722-98-7 Pregn-5-en-20-o... CAS#:1162-53-4 16-Dehydropregn...
DownStream 10
CAS#:566-78-9 Pregn-5-en-20-o... CAS#:387-79-1 17a-Hydroxypreg... CAS#:53-43-0 Dehydroepiandro... CAS#:521-17-5 Androstenediol
CAS#:1224-94-8 (3S,8R,9S,10R,1... CAS#:901-57-5 5-PREGNEN-3BETA... CAS#:520-88-7 5-PREGNEN-3-BET... CAS#:14148-09-5 Pregnan-20-one,...
CAS#:1778-02-5 3β-acetoxy-preg... CAS#:145-14-2 20(S)-Hydroxypr...

HS Code	2937290090

Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).

PLoS ONE 10 , e0141252, (2015)

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Hexabromocyclododecane (HBCDD), a brominated flame retardant added to various consumer products, is a ubiquitous environmental contaminant. We have previously shown that 6-hour exposure to HBCDD distu...

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

EINECS 205-647-4

prenolon

ZK-5553

MFCD00003628

Pregn-5-en-20-one, 3-hydroxy-

prenenolone

Pregnelone

Pregnenlolone

3-Hydroxypregn-5-en-20-one

Pregnenolone

3β-Hydroxy-5-pregnen-20-one

5-Pregnen-3β-ol-20-one

pregnolon

Progeserone

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China
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China
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China
Product Name: Pregnenolone
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Purity: 99.0%
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Pregnenolone

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