Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sulfamethazine
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57-68-1

57-68-1 structure

Name: Sulfamethazine
Chemical Name: sulfamethazine
CAS Number: 57-68-1
Molecular Formula: C₁₂H₁₄N₄O₂S
Molecular Weight: 278.330
Catalog: Organic raw materials Hydrocarbon compounds and their derivatives Hydrocarbon halide
Create Date: 2018-02-08 08:00:00
Modify Date: 2026-06-30 17:15:16
Sulfamethazine is a sulfonamide antibacterial.Target: AntibacterialSulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections. Sulfamethazine blocks the synthesis of dihydrofolic acid by inhibiting dihydropteroate synthase. In addition, sulfamethazine is a structural analog and competitive antagonist of para-aminobenzoic acid (PABA) and can inhibit normal bacterial utilization of PABA for the synthesis of folic acid, which is an important metabolite in DNA synthesis [1, 2].

Name	sulfamethazine
Synonyms	N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide Vertolan Dimidim-R 2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine Intradine Dimezathine Sulphix Cremomethazine n(1)-(4,6-dimethyl-2-pyrimidyl)sulfanilamide N(sup1)-(2,6-Dimethylpyrimid-4-yl)sulfanilamide Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl) Superstyl 4,6-Dimethyl-2-sulfanilamidopyrimidine EINECS 200-346-4 Calfspan tablets Sulfamethazine Solution, 100ppm (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin Sulfodimezine Sulphadimidine Superstil 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-Benzensulfonamide 4-amino-n-(4,6-dimethyl-2-pyrimidinyl)-benzenesulfonamid 4-Amino-N-(2,6-dimethyl-2-pyrimidinyl)ben-zenesulfonamide Diazil A-502 Dimidin-R SulfaMethazine, (LC&T 4-AMINO-N-(4,6-DIMETHYL-2-PYRIMIDINYL)BENZENESULFONAMIDE 6-(4’-aminobenzol-sulfonamido)-2,4-dimethylpyrimidin Hava-Span Sulphadimethylpyrimidine Sulphamethazine 6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin SulfadiMidine COS Sulphamethasine LABOTEST-BB LT00114898 benzenesulfonamide,4-amino-N-(4,6-dimethyl-2-pyrimiidinyl) Diazilsulfadine MFCD00006066 Mermeth L-30 Sulfadimidine 4-Amino-N-(4,6-dimethyl-2-pyrimidyl)benzenesulfonamide 4,6-Dimethylsulfadiazine 4,6-DIMETHYLSULFADIAZINE Sulka k boluses 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide Sulphodimezine Azolmetazin Sulphamezathine Benzensulfonamide,4-amino-N-(4,6-dimethyl-2-pyrimidinyl) Sulphamidine 2-sulfanilamido-4,6-dimethylpyrimidine Sulfadimidine sulfadimidine Metazin 4-amino-N-(4,6-dimethyl-2-pyrimiidinyl)benzenesulfonamide 4-AMINO-N-(4,6-DIMETHYL-PYRIMIDIN-2-YL)-BENZENESULFONAMIDE 2-(p-aminobenzenesulfonamido)-4,6-dimethylpyrimidine n(1)-(4,6-dimethyl-2-pyrimidinyl)-sulfanilamid bn2409 Zinosan N Kelametazine

Description	Sulfamethazine is a sulfonamide antibacterial.Target: AntibacterialSulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections. Sulfamethazine blocks the synthesis of dihydrofolic acid by inhibiting dihydropteroate synthase. In addition, sulfamethazine is a structural analog and competitive antagonist of para-aminobenzoic acid (PABA) and can inhibit normal bacterial utilization of PABA for the synthesis of folic acid, which is an important metabolite in DNA synthesis [1, 2].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Perez, S., P. Eichhorn, and D.S. Aga, Evaluating the biodegradability of sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim at different stages of sewage treatment. Environ Toxicol Chem, 2005. 24(6): p. 1361-7. [2]. Kaniou, S., et al., Photocatalytic oxidation of sulfamethazine. Chemosphere, 2005. 60(3): p. 372-80.

Density	1.4±0.1 g/cm3
Boiling Point	526.2±52.0 °C at 760 mmHg
Melting Point	197 °C
Molecular Formula	C₁₂H₁₄N₄O₂S
Molecular Weight	278.330
Flash Point	272.1±30.7 °C
Exact Mass	278.083740
PSA	106.35000
LogP	0.80
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.644
Storage condition	2-8°C
Stability	Stable, but light sensitive. Incompatible with strong oxidizing agents.
Water Solubility	150mg/100mL (29 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9275000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4,6-dimethyl-2-pyrimidinyl)-

CAS REGISTRY NUMBER :: 57-68-1

BEILSTEIN REFERENCE NO. :: 0261304

LAST UPDATED :: 199706

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C12-H14-N4-O2-S

MOLECULAR WEIGHT :: 278.36

WISWESSER LINE NOTATION :: T6N CNJ BMSWR DZ& D1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 27,141,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,392,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1060 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 16,804,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 27,141,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1776 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,163,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 11,149,1959 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52560 mg/kg/2Y-C

TOXIC EFFECTS :: Endocrine - changes in thyroid weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 22,175,1987 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 104 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,157,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5000 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumor types after systemic administration not seen spontaneously

REFERENCE :: ACRAAX Acta Radiologica. (Stockholm, Sweden) V.1-58, 1921-62. For publisher information, see ACRDA8. Volume(issue)/page/year: 37,258,1952

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 419 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 27,455,1989 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6850 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB83-151035

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8650 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB83-151035

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 46200 mg/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 81,259,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25200 mg/kg

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB85-105690 *** REVIEWS *** TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(2),5,1982 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83543 No. of Facilities: 1105 (estimated) No. of Industries: 6 No. of Occupations: 12 No. of Employees: 6918 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83543 No. of Facilities: 1303 (estimated) No. of Industries: 4 No. of Occupations: 22 No. of Employees: 17376 (estimated) No. of Female Employees: 2625 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S23-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	WO9275000
HS Code	2935009090

Precursor 10
100-90-3 767-15-7 121-60-8 153312-38-0
98-74-8 4472-44-0 121-61-9 63-74-1
123-54-6 57-67-0
DownStream 9
2315-08-4 108-79-2 63-74-1 121-57-3
767-15-7 108-95-2 100-90-3 37560-05-7
85828-79-1

HS Code	2935002000
Summary	2935002000. VAT:17.0%. Tax rebate rate:9.0%. Supervision conditions:A(certificate of inspection for goods inward). MFN tariff:6.5%. General tariff:35.0%

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