15722-48-2

15722-48-2 structure

Name: 5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoic acid)
Chemical Name: olsalazine
CAS Number: 15722-48-2
Molecular Formula: C₁₄H₁₀N₂O₆
Molecular Weight: 302.23900
Catalog: API Digestive system medication Acid and gastric mucosal protective drugs
Create Date: 2018-08-14 17:04:10
Modify Date: 2024-01-02 06:02:48
Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity[1][2].

Name	olsalazine
Synonyms	Olsalazine 5,5'-azosalicylic acid Azodisal Olsalazina Olsalazinum [Latin] 3,3'-Azobis(6-hydroxybenzoic acid) 6,6'-Dihydroxy-3,3'-azo-di-benzoesaeure 5,5'-Azobis(salicylic acid) 6,6'-dihydroxy-3,3'-azo-di-benzoic acid Eriochromflavin-A C.I. Mordant Yellow 5 Dipentum Olsalazinum MFCD00602469 5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid Rasal

Description	Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	IC50: 0.39 mM (LTB4)[1]
References	[1]. Nielsen, O.H., H.W. Verspaget, and J. Elmgreen, Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Aliment Pharmacol Ther, 1988. 2(3): p. 203-11. [2]. Horn H, et al. Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. Scand J Gastroenterol. 1991 Aug;26(8):867-79.

REFERENCE :: AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 100,238,1996

Hazard Codes	Xi
HS Code	2927000090

HS Code	2927000090
Summary	2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%