5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoic acid)

Modify Date: 2024-01-02 06:02:48

5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoic acid) structure	Common Name	5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoic acid)
	CAS Number	15722-48-2	Molecular Weight	302.23900
	Density	1.55g/cm3	Boiling Point	653.233ºC at 760 mmHg
	Molecular Formula	C₁₄H₁₀N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	348.863ºC

Use of 5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoic acid)

Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity[1][2].

Name	olsalazine
Synonym	More Synonyms

Description	Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	IC50: 0.39 mM (LTB4)[1]
References	[1]. Nielsen, O.H., H.W. Verspaget, and J. Elmgreen, Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Aliment Pharmacol Ther, 1988. 2(3): p. 203-11. [2]. Horn H, et al. Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. Scand J Gastroenterol. 1991 Aug;26(8):867-79.

Density	1.55g/cm3
Boiling Point	653.233ºC at 760 mmHg
Molecular Formula	C₁₄H₁₀N₂O₆
Molecular Weight	302.23900
Flash Point	348.863ºC
Exact Mass	302.05400
PSA	139.78000
LogP	2.90960
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.678

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG3482500

CHEMICAL NAME :: Benzoic acid, 3,3'-azobis(6-hydroxy-

CAS REGISTRY NUMBER :: 15722-48-2

LAST UPDATED :: 199807

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1714 mg/kg/34W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - interstitial nephritis

REFERENCE :: AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 100,238,1996

Hazard Codes	Xi
HS Code	2927000090

Precursor 5
CAS#:89-57-6 5-Aminosalicyli... CAS#:69-72-7 Salicylic acid CAS#:119-36-8 Methyl salicylate CAS#:2516-96-3 2-Chloro-5-nitr...
CAS#:62773-65-3 ethyl 5-amino-2...
DownStream 1
CAS#:89-57-6 5-Aminosalicyli...

HS Code	2927000090
Summary	2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Olsalazine

5,5'-azosalicylic acid

Azodisal

Olsalazina

Olsalazinum [Latin]

3,3'-Azobis(6-hydroxybenzoic acid)

6,6'-Dihydroxy-3,3'-azo-di-benzoesaeure

5,5'-Azobis(salicylic acid)

6,6'-dihydroxy-3,3'-azo-di-benzoic acid

Eriochromflavin-A

C.I. Mordant Yellow 5

Dipentum

Olsalazinum

MFCD00602469

5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid

Rasal

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Olsalazine
Price: Check
Purity: 99.85%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: OLSALAZINE 15722-48-2
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.