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Product Name: Terpinine-4-ol
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China
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China
Product Name: Terpinen-4-ol
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China
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562-74-3

562-74-3 structure

Name: Terpinine-4-ol
Chemical Name: 4-terpineol
CAS Number: 562-74-3
Molecular Formula: C₁₀H₁₈O
Molecular Weight: 154.249
Catalog: Flavors and spices Synthetic spice Alcoholic spice Terpene alcohol
Create Date: 2018-02-11 08:00:00
Modify Date: 2024-01-02 11:14:42
Terpinen-4-ol (4-Carvomenthenol), a naturally occurring monoterpene, is the main bioactive component of tea-tree oil. Terpinen-4-ol suppresses inflammatory mediator production by activated human monocytes. Terpinen-4-ol significantly enhances the effect of several chemotherapeutic and biological agents[1][2][3].

Name	4-terpineol
Synonyms	3-Cyclohexen-1-ol, 4-methyl-1- (1-methylethyl)- EINECS 209-235-5 1-Isopropyl-4-methyl-3-cyclohexen-1-ol 4-methyl-1-[1-methylethyl]-3-cyclohexen-1-ol 4-terpineol 4-terpinenol terpineol-4 Terpine-4-ol Terpene-4-ol Terpinenol-4 p-menth-1-en-4-ol (±)-4-Terpineol Terpin-4-ol 1-(1-Methylethyl)-4-methyl-3-cyclohexen-1-ol (±)-Terpinen-4-ol Terpinen-4-ol Terpinenolu-4 3-Cyclohexen-1-ol, 4-methyl-1-(1-methylethyl)- dl-4-Terpineol 4-Methyl-1-(1-methylethyl)-3-cyclohexene-1-ol FEMA 2248 1-Isopropyl-4-methylcyclohex-3-en-1-ol MFCD00001562

Description	Terpinen-4-ol (4-Carvomenthenol), a naturally occurring monoterpene, is the main bioactive component of tea-tree oil. Terpinen-4-ol suppresses inflammatory mediator production by activated human monocytes. Terpinen-4-ol significantly enhances the effect of several chemotherapeutic and biological agents[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Hart PH, et al. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Inflamm Res. 2000 Nov;49(11):619-26. [2]. Shapira S, et al. Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers. PLoS One. 2016 Jun 8;11(6):e0156540.

Density	0.9±0.1 g/cm3
Boiling Point	209.0±0.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₈O
Molecular Weight	154.249
Flash Point	79.4±0.0 °C
Exact Mass	154.135757
PSA	20.23000
LogP	2.99
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.485
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	Very slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OT0175110

CHEMICAL NAME :: para-Menth-1-en-4-ol

CAS REGISTRY NUMBER :: 562-74-3

BEILSTEIN REFERENCE NO. :: 1906603

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H18-O

MOLECULAR WEIGHT :: 154.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,833,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,833,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 8,433,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1016 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CCHCDE Zhonghua Jiehe He Huxixi Jibing Zazhi. Chinese Journal of Tuberculosis and Respiratory Diseases. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1978- Volume(issue)/page/year: 4(4),203,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 8,433,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 8,433,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 8,433,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,833,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2137 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1167 (estimated) No. of Female Employees: 51 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36-S37/39
WGK Germany	2
RTECS	OT0175110

Precursor 8
105273-31-2 470-67-7 138-86-3 4584-23-0
763-10-0 25570-95-0 2009-00-9 27621-71-2
DownStream 6
470-67-7 586-62-9 99-86-5 99-85-4
586-63-0 4821-04-9

562-74-3	111013-09-3
30651-03-7	26458-74-2
542-27-8	65949-99-7
3336-49-0	2380-84-9
771555-21-6	81793-47-7
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
479-97-0	6906-52-1
930439-75-1	1018584-77-4
926521-24-6	1375289-11-4