Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dipentene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: limonene
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

138-86-3

138-86-3 structure

Name: limonene
Chemical Name: limonene
CAS Number: 138-86-3
Molecular Formula: C₁₀H₁₆
Molecular Weight: 136.234
Catalog: Organic raw materials Hydrocarbon compounds and their derivatives Acyclic hydrocarbon
Create Date: 2018-02-05 08:00:00
Modify Date: 2026-06-30 08:08:16
Limonene is a monoterpene in citrus peel oil. A popular disinfectant and food preservative. Antimicrobial activities[1]. Anti-proliferative activities[2]. Antioxidant and anti-inflammatory effect[3].

Name	limonene
Synonyms	(±)-limonene(dipentene) L-P-MENTHA-1,8-DIENE (R)-(+)-P-MENTHA-1,8-DIENE EINECS 227-815-6 (R)-(+)-4-ISOPROPENYL-1-METHYL-1-CYCLOHEXENE D(+) LIMONENE TERPENE SOLVENT, LOW ODOR Di-p-mentha-1,8-diene (±)-LiMonene, Mixture of isoMers Food ade d-Limonene 4-(1-methylethenyl)-1-methyl-cyclohexene D-1-METHYL-4-ISOPROPENYL-D-CYCLOHEXENE (R)-4-ISOPROPENYL-1-METHYL-CYCLOHEXENE Methyl-4-isopropenyl-1-cyclohexene CITRAL TERPENES Methyl-4-isopropenylcyclohexene cyclohexene,1-methyl-4-(1-methylethylidene)-,(±) Dipanol D-LIMONENE DL-p-mentha-1,8-diene Methyl-4-(1-methylethenyl)cyclohexene Unitene (±)-(RS)-limonene Nesol (-)-P-MENTHA-1,8-DIENE cyclohexene,1-methyl-4-(1-methylethenyl) 1-Methyl-4-methylethenylcyclohexene dipentene200 4-ISOPROPENYL-1-METHYL-1-CYCLOHEXENE Cinen (R)-4-ISOPROPENYL-1-METHYL-1-CYCLOHEXENE Eulimen limonene, (±)-isomer dipentene (p-Mentha-1,8-diene) 4-Isopropenyl-1-methylcyclohexene DL-p-1,8-menthadiene Limonene DL-dipentene (R)-(+)-LIMONENE 1,8-p-Mentadiene Dipentene,.,ca. , remainder mainly beta-phellandrene 1-methyl-4-(prop-1-en-2-yl)cyclohexene Cyclohexene, 1-methyl-4-(1-methylethenyl) (S)-(-)-4-ISOPROPENYL-1-METHYL-1-CYCLOHEXENE DL-LIMONENE p-mentha-1,8-diene DL-LIMONENE (MIXTURE OF D- AND L-FORM CA acintenedpdipentene Cinene / Dipentene (±)-p-Mentha-1,8-diene Mentha-1,8-diene, DL (±)-Limonene mixture of isomers CITRUS TERPENE Dipentene Natural (-)-LIMONENE L-LIMONENE alpha-Limonene (±)-Limonene (+/-)-LiMonene, Histological ade Dipentene,(±)-Limonene, p-Mentha-1,8-diene DL-Limonene (mixture of D- and L-form ~1:1) Cajuten Depanol 1,8-p-Menthadiene (R)-(+)-ISOPROPENYL-1-METHYL-1-CYCLOHEXENE a-limonene 1-methyl-4-(1-methylethenyl)-cyclohexen p-menth-1,8-diene MFCD00001558 Dipenten D-P-MENTHA-1,8-DIENE LIMONENE(P) Cyclohexene, 1-methyl-4-(1-methylethynyl) LIMONENE Mentha-1,8-diene S-(-)-CVENE α-Limonene Dipentene ade (±)-1,8-p-menthadiene,(±)-limonene D-CAJUTENE delta-1,8-Terpodiene dycom Ciene C06078 D-CINENE Cinene

Description	Limonene is a monoterpene in citrus peel oil. A popular disinfectant and food preservative. Antimicrobial activities[1]. Anti-proliferative activities[2]. Antioxidant and anti-inflammatory effect[3].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Infection Natural Products >> Terpenoids and Glycosides
Target	Bacterial[1]
In Vitro	Acute toxicity to limonene is largely due to the common oxidation product limonene-hydroperoxide. The mutant protein AhpCL177Q 35 is able to alleviate this toxicity by reducing the hydroperoxide to a more benign compound[1]. Limonene exerts anti-proliferative action on a lymphoma cell line without modifying normal lymphocyte viability[2].
In Vivo	Limonene (50-100 mg/kg) exerts gastroprotection through local mucosal defense mechanisms, such as increasing the mucus production, modulation of the oxidative stress and inflammatory response and inhibition of Nf-κb expression[3].
References	[1]. Chubukov V, et al. Acute Limonene Toxicity in Escherichia coli Is Caused by Limonene Hydroperoxide and Alleviated by a Point Mutation in Alkyl Hydroperoxidase AhpC. Appl Environ Microbiol. 2015 Jul;81(14):4690-6. [2]. Roberto D, et al. Antioxidant activity of limonene on normal murine lymphocytes: relation to H2O2 modulation and cell proliferation. Basic Clin Pharmacol Toxicol. 2010 Jan;106(1):38-44. [3]. de Souza MC, et al. Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression. Phytomedicine. 2018 Sep 4;53:37-42.

Density	0.8±0.1 g/cm3
Boiling Point	175.4±20.0 °C at 760 mmHg
Melting Point	-84--104 °C
Molecular Formula	C₁₀H₁₆
Molecular Weight	136.234
Flash Point	42.8±0.0 °C
Exact Mass	136.125198
LogP	4.45
Vapour density	4.7 (vs air)
Vapour Pressure	1.5±0.2 mmHg at 25°C
Index of Refraction	1.468
Stability	Stable. Flammable. Incompatible with strong oxidizing agents.
Water Solubility	<1 g/100mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS8100000

CHEMICAL NAME :: p-Mentha-1,8-diene

CAS REGISTRY NUMBER :: 138-86-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H16

MOLECULAR WEIGHT :: 136.26

WISWESSER LINE NOTATION :: L6UTJ A1 DY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,703,1974 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,703,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5550 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 24,700,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1010 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 24,700,1989

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RCTOE4 Reviews of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.98- 1987- Volume(issue)/page/year: 113,47,1990 *** REVIEWS *** TOXICOLOGY REVIEW ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 78,99,1972 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1342 No. of Facilities: 3959 (estimated) No. of Industries: 70 No. of Occupations: 60 No. of Employees: 45463 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1342 No. of Facilities: 12642 (estimated) No. of Industries: 103 No. of Occupations: 90 No. of Employees: 185336 (estimated) No. of Female Employees: 45650 (estimated)

Symbol	GHS02, GHS07, GHS09
Signal Word	Warning
Hazard Statements	H226-H315-H317-H410
Precautionary Statements	P273-P280-P501
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;N:Dangerousfortheenvironment;
Risk Phrases	R10;R38;R43;R50/53
Safety Phrases	S24-S37-S60-S61
RIDADR	UN 2052 3/PG 3
WGK Germany	2
RTECS	OS8350000
Packaging Group	III
Hazard Class	3
HS Code	2942000000

Precursor 9
1195-92-2 61585-35-1 80-56-8 2451-01-6
79433-08-2 106-24-1 79433-10-6 99-49-0
82096-14-8
DownStream 10
112358-23-3 562-74-3 491-09-8 14576-08-0
26946-66-7 26946-68-9 470-82-6 98-55-5
80-53-5 99-49-0