Top Suppliers:I want be here
Related CAS#:
36476-78-5 193693-64-0
142253-55-2 97628-92-7
97628-91-6 94985-27-0
102624-96-4 97639-63-9
791775-01-4 36476-87-6
1249389-25-0 150884-82-5
66970-33-0 1342905-66-1
1378519-48-2 1342227-88-6
1461869-43-1 1375909-84-4
1309933-75-2 1343368-57-9

36476-78-5

36476-78-5 structure
36476-78-5 structure
  • Name: Azetidine-3-carboxylic acid
  • Chemical Name: 3-Azetidinecarboxylic Acid
  • CAS Number: 36476-78-5
  • Molecular Formula: C4H7NO2
  • Molecular Weight: 101.104
  • Catalog: Chemical reagent Organic reagent Imine, hydrazine
  • Create Date: 2018-03-29 08:00:00
  • Modify Date: 2024-01-02 19:53:49
  • Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Name 3-Azetidinecarboxylic Acid
Synonyms Azetidine-3-carboxylic Acid
3-Azetidinecarboxylic acid
MFCD00191763
3-Azetidine carboxylic acid
Description Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Density 1.3±0.1 g/cm3
Boiling Point 242.0±33.0 °C at 760 mmHg
Melting Point 286 °C (dec.)(lit.)
Molecular Formula C4H7NO2
Molecular Weight 101.104
Flash Point 100.1±25.4 °C
Exact Mass 101.047676
PSA 49.33000
LogP -0.86
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.499

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CM4310600
CHEMICAL NAME :
3-Azetidinecarboxylic acid
CAS REGISTRY NUMBER :
36476-78-5
BEILSTEIN REFERENCE NO. :
0385928
LAST UPDATED :
199710
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C4-H7-N-O2
MOLECULAR WEIGHT :
101.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C65,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C65,1991
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25-S22
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CM4310600
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Chemsrc provides CAS#:36476-78-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 36476-78-5 | Chemsrc address: https://m.chemsrc.com/en/baike/897714.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved