Azetidine-3-carboxylic acid

Modify Date: 2025-08-22 11:01:59

Azetidine-3-carboxylic acid Structure
Azetidine-3-carboxylic acid structure
 Common Name Azetidine-3-carboxylic acid
CAS Number 36476-78-5 Molecular Weight 101.104
Density 1.3±0.1 g/cm3 Boiling Point 242.0±33.0 °C at 760 mmHg
Molecular Formula C4H7NO2 Melting Point 286 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 100.1±25.4 °C

 Use of Azetidine-3-carboxylic acid


Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

 Names

Name 3-Azetidinecarboxylic Acid
Synonym More Synonyms

 Azetidine-3-carboxylic acid Biological Activity

Description Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 242.0±33.0 °C at 760 mmHg
Melting Point 286 °C (dec.)(lit.)
Molecular Formula C4H7NO2
Molecular Weight 101.104
Flash Point 100.1±25.4 °C
Exact Mass 101.047676
PSA 49.33000
LogP -0.86
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.499

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CM4310600
CHEMICAL NAME :
3-Azetidinecarboxylic acid
CAS REGISTRY NUMBER :
36476-78-5
BEILSTEIN REFERENCE NO. :
0385928
LAST UPDATED :
199710
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C4-H7-N-O2
MOLECULAR WEIGHT :
101.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C65,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C65,1991

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25-S22
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CM4310600
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles2

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 Synonyms

Azetidine-3-carboxylic Acid
3-Azetidinecarboxylic acid
MFCD00191763
3-Azetidine carboxylic acid
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