Azetidine-3-carboxylic acid

Modify Date: 2024-01-02 19:53:49

Azetidine-3-carboxylic acid structure	Common Name	Azetidine-3-carboxylic acid
	CAS Number	36476-78-5	Molecular Weight	101.104
	Density	1.3±0.1 g/cm3	Boiling Point	242.0±33.0 °C at 760 mmHg
	Molecular Formula	C₄H₇NO₂	Melting Point	286 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	100.1±25.4 °C

Use of Azetidine-3-carboxylic acid

Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

Name	3-Azetidinecarboxylic Acid
Synonym	More Synonyms

Description	Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.3±0.1 g/cm3
Boiling Point	242.0±33.0 °C at 760 mmHg
Melting Point	286 °C (dec.)(lit.)
Molecular Formula	C₄H₇NO₂
Molecular Weight	101.104
Flash Point	100.1±25.4 °C
Exact Mass	101.047676
PSA	49.33000
LogP	-0.86
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.499

Azetidine-3-carboxylic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CM4310600

CHEMICAL NAME :: 3-Azetidinecarboxylic acid

CAS REGISTRY NUMBER :: 36476-78-5

BEILSTEIN REFERENCE NO. :: 0385928

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H7-N-O2

MOLECULAR WEIGHT :: 101.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C65,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C65,1991

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25-S22
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CM4310600
HS Code	2933990090

Precursor 3
CAS#:94985-27-0 1-Benzyl-3-azet... CAS#:26096-30-0 (1-benzylazetid... CAS#:87-69-4 Tartaric acid
DownStream 6
CAS#:343238-58-4 1-Methyl-3-azet... CAS#:875629-26-8 1-Methyl-3-azet... CAS#:97628-92-7 1-benzyloxycarb... CAS#:1001026-41-0 1-(2,2,2-triflu...
CAS#:100202-39-9 Methyl azetidin... CAS#:142253-55-2 1-Boc-azetidine...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Beta-proline analogues as agonists at the strychnine-sensitive glycine receptor.

J. Med. Chem. 35 , 233, (1992)

3-Carboxy-3,4-dehydropyrrolidine was found to bind with affinity equal to that of glycine in a [3H]strychnine binding assay. Simple substitution of the 1-, 2-, 4-, or 5-position resulted in marked los...

Weed Sci. 38 , 315, (1990)

Azetidine-3-carboxylic Acid

3-Azetidinecarboxylic acid

MFCD00191763

3-Azetidine carboxylic acid

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Azetidine-3-carboxylic acid
Price: ￥128.0/5g ￥448.0/25g
Purity: 98.0%
Stocking Period: 3 Day
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Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: Azetidine-3-carboxylic acid
Price: ￥Inquiry/1kg
Purity: 98.0%
Stocking Period: 10 Day
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Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: Azetidine-3-carboxylic acid
Price: ￥555500.0/100kg
Purity: 98.0%
Stocking Period: 90 Day
Contact: Lihua Yang

DC Chemicals Limited
China
Product Name: Azetidine-2-carboxylic acid
Price: $50.0/100mg $100.0/250mg $200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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Nanjing Peptide Biotech Ltd
China
Product Name: Azetidine-3-carboxylic acid
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-Azetidinecarboxylic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 3-Azetidinecarboxylic Acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Azetidine-3-carboxylic acid

Use of Azetidine-3-carboxylic acid

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