DC Chemicals Limited
China
Product Name: (3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine hydrochloride)
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: gamma-Butyrobetaine
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: (3-Carboxypropyl)trimethylammonium chloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

6249-56-5

6249-56-5 structure

Name: (3-Carboxypropyl)trimethylammonium chloride
Chemical Name: 3-carboxypropyl(trimethyl)azanium,chloride
CAS Number: 6249-56-5
Molecular Formula: C₇H₁₆ClNO₂
Molecular Weight: 181.660
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-02-21 08:00:00
Modify Date: 2024-01-11 14:27:31
(3-Carboxypropyl)trimethylammonium chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.

Name	3-carboxypropyl(trimethyl)azanium,chloride
Synonyms	g-Butyrobetaine Hydrochloride 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride Trimethylaminobutyrate 3-carboxy-N,N,N-trimethylpropan-1-ammonium chloride 3-Carboxy-N,N,N-trimethyl-1-propanaminium chloride (3-Carboxypropyl)trimethylammonium chloride Butyrobetaine chloride γ-Butyrobetaine hydrochloride MFCD00011905 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-, chloride (1:1) Deoxycarnitine hydrochloride 3-carboxy-N,N,N-trimethylpropanaminium chloride

Description	(3-Carboxypropyl)trimethylammonium chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease
In Vivo	(3-Carboxypropyl)trimethylammonium chloride is produced as an intermediary metabolite by gut microbes of L-Carnitine to TMAO[1]. (3-Carboxypropyl)trimethylammonium chloride is implicated in arteriosclerosis and long-term cardiovascular death[2].
References	[1]. Koeth RA, et al. γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab. 2014 Nov 4;20(5):799-812. [2]. Susumu Ogawa, et al. The Dynamics of Carnitine, γ-butyrobetaine and Trimethylamine N-oxide in Diabetics and the Effects of Changes in Renal Function. Ogawa et al., J Nephrol Ren Dis 2017, 1:2

Melting Point	220ºC (dec.)(lit.)
Molecular Formula	C₇H₁₆ClNO₂
Molecular Weight	181.660
Exact Mass	181.086960
PSA	37.30000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP3850000

CHEMICAL NAME :: Ammonium, (3-carboxypropyl)trimethyl-, chloride

CAS REGISTRY NUMBER :: 6249-56-5

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H15-N-O2.Cl

MOLECULAR WEIGHT :: 180.68

WISWESSER LINE NOTATION :: QV3K1&1&1 &Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 3,28,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 475 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,233,1963

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
HS Code	2923900090

51963-62-3

~96%

6249-56-5

Literature: Gasparini, Giulio; Prins, Leonard J.; Scrimin, Paolo Angewandte Chemie - International Edition, 2008 , vol. 47, # 13 p. 2475 - 2479

56-12-2

74-88-4

~52%

6249-56-5

Literature: Morano, Cain; Zhang, Xin; Fricker, Lloyd D. Analytical Chemistry, 2008 , vol. 80, # 23 p. 9298 - 9309

3153-37-5

75-50-3

~61%

6249-56-5

Literature: Beierlein, Christian H.; Breit, Bernhard; Paz Schmidt, Roberto A.; Plattner, Dietmar A. Organometallics, 2010 , vol. 29, # 11 p. 2521 - 2532

872-50-4

6249-56-5

Literature: Synthesis, , # 6 p. 468 - 469

69954-66-1

6249-56-5

Literature: Synthesis, , # 6 p. 468 - 469

3153-36-4

75-50-3

6249-56-5

Literature: Journal of Organic Chemistry, , vol. 55, # 4 p. 1334 - 1338

693-11-8

6257-10-9

6249-56-5

Literature: Synthesis, , # 6 p. 468 - 469

627-00-9

75-50-3

6249-56-5

Literature: Journal of Molecular Structure, , vol. 563-564, p. 555 - 564

Precursor 10
51963-62-3 56-12-2 74-88-4 3153-37-5
75-50-3 872-50-4 69954-66-1 3153-36-4
693-11-8 6257-10-9
DownStream 0

HS Code	2923900090
Summary	2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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