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857891-82-8

857891-82-8 structure
857891-82-8 structure
  • Name: Azido-PEG8-amine
  • Chemical Name: 2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
  • CAS Number: 857891-82-8
  • Molecular Formula: C18H38N4O8
  • Molecular Weight: 438.51600
  • Catalog: Chemical reagent Organic reagent Azide
  • Create Date: 2017-03-04 16:00:23
  • Modify Date: 2024-01-04 18:24:03
  • Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Synonyms Azido-PEG-amine (n=8)
O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol
O-(2-Aminoethyl)-O inverted exclamation marka-(2-azidoethyl)heptaethylene glycol
26-Azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-amine
Description Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C18H38N4O8
Molecular Weight 438.51600
Exact Mass 438.26900
PSA 149.61000
LogP 0.54126
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
WGK Germany 3