Azido-PEG8-amine

Modify Date: 2024-01-04 18:24:03

Azido-PEG8-amine Structure
Azido-PEG8-amine structure
Common Name Azido-PEG8-amine
CAS Number 857891-82-8 Molecular Weight 438.51600
Density N/A Boiling Point N/A
Molecular Formula C18H38N4O8 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Azido-PEG8-amine


Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Synonym More Synonyms

 Azido-PEG8-amine Biological Activity

Description Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C18H38N4O8
Molecular Weight 438.51600
Exact Mass 438.26900
PSA 149.61000
LogP 0.54126
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles1

More Articles
Spatioselective Modification of Bicompartmental Polymer Particles and Fibers via Huisgen 1, 3‐Dipolar Cycloaddition Bhaskar S, et al.

Macromol. Rapid Commun. 29(20) , 1655-1660, (2008)

 Synonyms

Azido-PEG-amine (n=8)
O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol
O-(2-Aminoethyl)-O inverted exclamation marka-(2-azidoethyl)heptaethylene glycol
26-Azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-amine
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