20784-50-3

20784-50-3 structure

Name: Isobavachalcone
Chemical Name: Isobavachalcone
CAS Number: 20784-50-3
Molecular Formula: C₂₀H₂₀O₄
Molecular Weight: 324.370
Catalog: Natural product Chalcone
Create Date: 2018-09-28 15:13:27
Modify Date: 2025-08-21 20:44:23
Isobavachalcone(Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.IC50 value:Target: Isobavachalcone inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Isobavachalcone exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Isobavachalcone hows antifungal activity.

Name	Isobavachalcone
Synonyms	(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 4-Hydroxyisocordoim 2',4',4-trihydroxy-3'-prenylchalcone 4-Hydroxyisocordoin Isobacachalcone 4,2',4'-trihydroxy-3'-prenylchalcone (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one 2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)- Corylifolinin

Description	Isobavachalcone(Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.IC50 value:Target: Isobavachalcone inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Isobavachalcone exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Isobavachalcone hows antifungal activity.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer Natural Products >> Flavonoids
References	[1]. Jing Hui; Zhou Xinglu; Dong Xiaowu; Cao Ji; Zhu Hong; Lou Jianshu; Hu Yongzhou; He Qiaojun; Yang Bo Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells.Cancer letters (2010), 294(2):167-177 [2]. Nishimura R et al. Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. Biol Pharm Bull. 2007 Oct;30(10):1878-83. [3]. Zhao S, et al. Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells.Int J Mol Med. 2012 Jul 16. [4]. Kuete V, Sandjo LP.Isobavachalcone: an overview.Chin J Integr Med. 2012 Jul;18(7):543-7. Epub 2012 Jul 7. [5]. Zhang Y, Chen Z.Separation of isomeric bavachin and isobavachalcone in the fructus Psoraleae by capillary electrophoresis-mass spectrometry.J Sep Sci. 2012 Jul;35(13):1644-50.

Hazard Codes	Xi
RIDADR	NONH for all modes of transport