77453-01-1
77453-01-1 structure
- Name: SKF 100398
- Chemical Name: β-MERCAPTO-β,β-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
- CAS Number: 77453-01-1
- Molecular Formula: C53H77N13O11S2
- Molecular Weight: 1136.39000
- Catalog: Signaling Pathways GPCR/G Protein Vasopressin Receptor
- Create Date: 2018-12-22 21:57:38
- Modify Date: 2024-01-01 18:48:00
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SKF 100398 (d(CH2)5Tyr(Et)VAVP) is an arginine vasopressin (AVP) analogue, and acts as a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1].
| Name | β-MERCAPTO-β,β-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2 |
|---|---|
| Synonyms |
M.W. 1136.41 C53H77N13O11S2
type 1 arginine vasopressin antagonist (d(CH2)51,Tyr(Et)2,Val4,Arg8)-Vasopressin |
| Description | SKF 100398 (d(CH2)5Tyr(Et)VAVP) is an arginine vasopressin (AVP) analogue, and acts as a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1]. |
|---|---|
| Related Catalog | |
| In Vivo | SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP[1]. SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP[1]. Animal Model: Male Sprague-Dawley rats (250-300 g)[1] Dosage: 8 μg/kg Administration: Intravenous injection Result: Completely blocked the antidiuretic effect of exogenous AVP (4 ng/kg body wt i.v.). |
| References |
| Density | 1.44g/cm3 |
|---|---|
| Molecular Formula | C53H77N13O11S2 |
| Molecular Weight | 1136.39000 |
| Exact Mass | 1135.53000 |
| PSA | 431.92000 |
| LogP | 4.60970 |
| Index of Refraction | 1.676 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H332 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 20 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
