SKF 100398
SKF 100398 structure
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Common Name | SKF 100398 | ||
|---|---|---|---|---|
| CAS Number | 77453-01-1 | Molecular Weight | 1136.39000 | |
| Density | 1.44g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C53H77N13O11S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SKF 100398SKF 100398 (d(CH2)5Tyr(Et)VAVP) is an arginine vasopressin (AVP) analogue, and acts as a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1]. |
| Name | β-MERCAPTO-β,β-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2 |
|---|---|
| Synonym | More Synonyms |
| Description | SKF 100398 (d(CH2)5Tyr(Et)VAVP) is an arginine vasopressin (AVP) analogue, and acts as a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1]. |
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| Related Catalog | |
| In Vivo | SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP[1]. SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP[1]. Animal Model: Male Sprague-Dawley rats (250-300 g)[1] Dosage: 8 μg/kg Administration: Intravenous injection Result: Completely blocked the antidiuretic effect of exogenous AVP (4 ng/kg body wt i.v.). |
| References |
| Density | 1.44g/cm3 |
|---|---|
| Molecular Formula | C53H77N13O11S2 |
| Molecular Weight | 1136.39000 |
| Exact Mass | 1135.53000 |
| PSA | 431.92000 |
| LogP | 4.60970 |
| Index of Refraction | 1.676 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H332 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 20 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
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SKF 100398 CAS#:77453-01-1 |
| Literature: Manning, Maurice; Lammek, Bernard; Kolodziejczyk, Alexander M. Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 701 - 706 |
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Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.
Proc. Natl. Acad. Sci. U. S. A. 92(4) , 1013-7, (1995) Water excretion by the kidney is regulated by the peptide hormone vasopressin. Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed fro... |
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Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems.
Nature 337(6208) , 648-51, (1989) Growth factors raise intracellular pH (pHi) by stimulating Na+/H+ exchange in the absence of HCO3-. In mutant cells that lack the Na+/H+ exchange activity, this alkalinization does not occur, and the ... |
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Pharmacological characterization of V1a vasopressin receptors in the rat cortical collecting duct.
Am. J. Physiol. 262 , F546-F553, (1992) Vasopressin receptors in distal segments of the rat nephron were identified in isolated tubules using two labeled ligands: the [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid), 2-(O-meth... |
| M.W. 1136.41 C53H77N13O11S2 |
| type 1 arginine vasopressin antagonist |
| (d(CH2)51,Tyr(Et)2,Val4,Arg8)-Vasopressin |