Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: (-)-JQ-1
  • Price: $550.0/100mg $950.0/250mg $1900.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


1268524-71-5

1268524-71-5 structure
1268524-71-5 structure
  • Name: (-)-JQ-1
  • Chemical Name: ()-jq1
  • CAS Number: 1268524-71-5
  • Molecular Formula: C23H25ClN4O2S
  • Molecular Weight: 456.988
  • Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
  • Create Date: 2016-04-12 17:08:59
  • Modify Date: 2024-01-21 15:03:00
  • (-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.

Name ()-jq1
Synonyms 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-
2-Methyl-2-propanyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
(R)-(-)-JQ1 Enantiomer
Description (-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.
Related Catalog
Target

BET bromodomain[1]

In Vitro (−)-JQ1 shows no significant interaction with any bromodomain. Besides, (−)-JQ1 enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1].
References

[1]. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.

[2]. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.

Density 1.3±0.1 g/cm3
Boiling Point 610.4±65.0 °C at 760 mmHg
Molecular Formula C23H25ClN4O2S
Molecular Weight 456.988
Flash Point 322.9±34.3 °C
Exact Mass 456.138672
PSA 97.61000
LogP 4.49
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.657
Storage condition -20°C
RIDADR NONH for all modes of transport