1268524-71-5
1268524-71-5 structure
- Name: (-)-JQ-1
- Chemical Name: ()-jq1
- CAS Number: 1268524-71-5
- Molecular Formula: C23H25ClN4O2S
- Molecular Weight: 456.988
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2016-04-12 17:08:59
- Modify Date: 2025-08-25 17:15:30
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(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.
| Name | ()-jq1 |
|---|---|
| Synonyms |
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-
2-Methyl-2-propanyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate (R)-(-)-JQ1 Enantiomer |
| Description | (-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect. |
|---|---|
| Related Catalog | |
| Target |
BET bromodomain[1] |
| In Vitro | (−)-JQ1 shows no significant interaction with any bromodomain. Besides, (−)-JQ1 enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 610.4±65.0 °C at 760 mmHg |
| Molecular Formula | C23H25ClN4O2S |
| Molecular Weight | 456.988 |
| Flash Point | 322.9±34.3 °C |
| Exact Mass | 456.138672 |
| PSA | 97.61000 |
| LogP | 4.49 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.657 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
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