(-)-JQ-1 structure
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Common Name | (-)-JQ-1 | ||
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CAS Number | 1268524-71-5 | Molecular Weight | 456.988 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 610.4±65.0 °C at 760 mmHg | |
Molecular Formula | C23H25ClN4O2S | Melting Point | N/A | |
MSDS | USA | Flash Point | 322.9±34.3 °C |
Use of (-)-JQ-1(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect. |
Name | ()-jq1 |
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Synonym | More Synonyms |
Description | (-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect. |
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Related Catalog | |
Target |
BET bromodomain[1] |
In Vitro | (−)-JQ1 shows no significant interaction with any bromodomain. Besides, (−)-JQ1 enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 610.4±65.0 °C at 760 mmHg |
Molecular Formula | C23H25ClN4O2S |
Molecular Weight | 456.988 |
Flash Point | 322.9±34.3 °C |
Exact Mass | 456.138672 |
PSA | 97.61000 |
LogP | 4.49 |
Vapour Pressure | 0.0±1.7 mmHg at 25°C |
Index of Refraction | 1.657 |
Storage condition | -20°C |
RIDADR | NONH for all modes of transport |
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Targeting bromodomains: epigenetic readers of lysine acetylation.
Nat. Rev. Drug Discov. 13(5) , 337-56, (2014) Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the development of several diseases. Acetyl-lysine modifications create dockin... |
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Epigenetic chemical probes. Müller S and Brown PJ
Clin. Pharmacol. Ther. 92(6) , 689-93, (2012)
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Targeting chromatin readers. James LI and Frye SV
Clin. Pharmacol. Ther. 93(4) , 312-4, (2013)
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6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)- |
2-Methyl-2-propanyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate |
(R)-(-)-JQ1 Enantiomer |