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  • Product Name: IOX1
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Related CAS#:
5852-78-8 199871-63-1
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5852-78-8

5852-78-8 structure
5852-78-8 structure
  • Name: 5-Carboxy-8-hydroxyquinoline
  • Chemical Name: 8-hydroxyquinoline-5-carboxylic acid
  • CAS Number: 5852-78-8
  • Molecular Formula: C10H7NO3
  • Molecular Weight: 189.167
  • Catalog: Biochemical Inhibitor Epigenetics Histone Demethylase Inhibitor
  • Create Date: 2016-09-16 09:56:54
  • Modify Date: 2024-01-08 16:12:10
  • IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeability resulting from itspolar C-5 carboxyl group.
Name 8-hydroxyquinoline-5-carboxylic acid
Synonyms 8XQ
8-Hydroxy-chinolin-5-carbonsaeure
5-Quinolinecarboxylic acid, 8-hydroxy-
8-hydroxy-quinoline-5-carboxylic acid
UNII-JM015YQC1C
5-Carboxy-8-hydroxyquinoline
IOX1
8-Hydroxy-5-quinolinecarboxylic acid
Description IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeability resulting from itspolar C-5 carboxyl group.
Related Catalog
References

[1]. Schiller R, et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71.
Density 1.5±0.1 g/cm3
Boiling Point 464.5±30.0 °C at 760 mmHg
Molecular Formula C10H7NO3
Molecular Weight 189.167
Flash Point 234.7±24.6 °C
Exact Mass 189.042587
PSA 70.42000
LogP 1.81
Appearance white to brown
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.730
Storage condition 2-8°C
Water Solubility DMSO: soluble10mg/mL, clear
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
Risk Phrases 22
RIDADR NONH for all modes of transport
HS Code 2933499090
1571-72-8 structure

1571-72-8

~51%

5852-78-8 structure

5852-78-8

Literature: Schiller, Rachel; Scozzafava, Giuseppe; Tumber, Anthony; Wickens, James R.; Bush, Jacob T.; Rai, Ganesha; Lejeune, Clarisse; Choi, Hwanho; Yeh, Tzu-Lan; Chan, Mun Chiang; Mott, Bryan T.; McCullagh, James S. O.; Maloney, David J.; Schofield, Christopher J.; Kawamura, Akane ChemMedChem, 2014 , vol. 9, # 3 p. 566 - 571
107-02-8 structure

107-02-8

1571-72-8 structure

1571-72-8

~49%

5852-78-8 structure

5852-78-8

Literature: Sosic, Izidor; Mirkovic, Bojana; Arenz, Katharina; Stefane, Bogdan; Kos, Janko; Gobec, Stanislav Journal of Medicinal Chemistry, 2013 , vol. 56, # 2 p. 521 - 533
148-24-3 structure

148-24-3

~%

5852-78-8 structure

5852-78-8

Literature: Lippmann; Fleissner Chemische Berichte, 1886 , vol. 19, p. 2468 Monatshefte fuer Chemie, 1887 , vol. 8, p. 311 Full Text Show Details v. Niementowski; Sucharda Chemische Berichte, 1916 , vol. 49, p. 16
856098-71-0 structure

856098-71-0

~%

5852-78-8 structure

5852-78-8

Literature: Matsumura Journal of the American Chemical Society, 1935 , vol. 57, p. 124,127
91569-25-4 structure

91569-25-4

~%

5852-78-8 structure

5852-78-8

Literature: Matsumura Journal of the American Chemical Society, 1935 , vol. 57, p. 124,127
536-25-4 structure

536-25-4

56-81-5 structure

56-81-5

~%

5852-78-8 structure

5852-78-8

Literature: v. Niementowski; Sucharda Chemische Berichte, 1916 , vol. 49, p. 16
99970-88-4 structure

99970-88-4

~%

5852-78-8 structure

5852-78-8

Literature: Clemo; Howe Journal of the Chemical Society, 1955 , p. 3552
5852-79-9 structure

5852-79-9

~%

5852-78-8 structure

5852-78-8

Literature: Clemo; Howe Journal of the Chemical Society, 1955 , p. 3552
5852-79-9 structure

5852-79-9

~%

35385-24-1 structure

35385-24-1

5852-78-8 structure

5852-78-8

Literature: Clemo; Howe Journal of the Chemical Society, 1955 , p. 3552
HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 5852-78-8 | Chemsrc address: https://m.chemsrc.com/en/baike/906591.html

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