Name | 8-hydroxyquinoline-5-carboxylic acid |
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Synonyms |
8XQ
8-Hydroxy-chinolin-5-carbonsaeure 5-Quinolinecarboxylic acid, 8-hydroxy- 8-hydroxy-quinoline-5-carboxylic acid UNII-JM015YQC1C 5-Carboxy-8-hydroxyquinoline IOX1 8-Hydroxy-5-quinolinecarboxylic acid |
Description | IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeability resulting from itspolar C-5 carboxyl group. |
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Related Catalog | |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 464.5±30.0 °C at 760 mmHg |
Molecular Formula | C10H7NO3 |
Molecular Weight | 189.167 |
Flash Point | 234.7±24.6 °C |
Exact Mass | 189.042587 |
PSA | 70.42000 |
LogP | 1.81 |
Appearance | white to brown |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.730 |
Storage condition | 2-8°C |
Water Solubility | DMSO: soluble10mg/mL, clear |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Hazard Codes | Xn |
Risk Phrases | 22 |
RIDADR | NONH for all modes of transport |
HS Code | 2933499090 |
~51% 5852-78-8 |
Literature: Schiller, Rachel; Scozzafava, Giuseppe; Tumber, Anthony; Wickens, James R.; Bush, Jacob T.; Rai, Ganesha; Lejeune, Clarisse; Choi, Hwanho; Yeh, Tzu-Lan; Chan, Mun Chiang; Mott, Bryan T.; McCullagh, James S. O.; Maloney, David J.; Schofield, Christopher J.; Kawamura, Akane ChemMedChem, 2014 , vol. 9, # 3 p. 566 - 571 |
~49% 5852-78-8 |
Literature: Sosic, Izidor; Mirkovic, Bojana; Arenz, Katharina; Stefane, Bogdan; Kos, Janko; Gobec, Stanislav Journal of Medicinal Chemistry, 2013 , vol. 56, # 2 p. 521 - 533 |
~% 5852-78-8 |
Literature: Lippmann; Fleissner Chemische Berichte, 1886 , vol. 19, p. 2468 Monatshefte fuer Chemie, 1887 , vol. 8, p. 311 Full Text Show Details v. Niementowski; Sucharda Chemische Berichte, 1916 , vol. 49, p. 16 |
~% 5852-78-8 |
Literature: Matsumura Journal of the American Chemical Society, 1935 , vol. 57, p. 124,127 |
~% 5852-78-8 |
Literature: Matsumura Journal of the American Chemical Society, 1935 , vol. 57, p. 124,127 |
~% 5852-78-8 |
Literature: v. Niementowski; Sucharda Chemische Berichte, 1916 , vol. 49, p. 16 |
~% 5852-78-8 |
Literature: Clemo; Howe Journal of the Chemical Society, 1955 , p. 3552 |
~% 5852-78-8 |
Literature: Clemo; Howe Journal of the Chemical Society, 1955 , p. 3552 |
~% 5852-78-8 |
Literature: Clemo; Howe Journal of the Chemical Society, 1955 , p. 3552 |
Precursor 7 | |
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DownStream 3 | |
HS Code | 2933499090 |
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Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |