Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Omtriptolide
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Pg490-88
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Omtriptolide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

195883-06-8

195883-06-8 structure

195883-06-8 structure

Name: Omtriptolide
Chemical Name: Omtriptolide
CAS Number: 195883-06-8
Molecular Formula: C₂₄H₂₈O₉
Molecular Weight: 460.47400
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-07-02 23:02:40
Modify Date: 2024-01-02 14:43:58
Omtriptolide (PG490-88) is a water soluble derivative prodrug of triptolide purified from the Chinese herb.

Name	Omtriptolide
Synonyms	triptolide succinate UNII-D36ELM729P YM 262 triptolide 14-succinate

Description	Omtriptolide (PG490-88) is a water soluble derivative prodrug of triptolide purified from the Chinese herb.
Related Catalog	Research Areas >> Inflammation/Immunology
Target	ERK
In Vitro	Triptolide, a traditional Chinese medicine, has anti-inflammatory, antiproliferative, and proapoptotic properties[1].
In Vivo	In a mouse model of cisplatin-induced AKI, omtriptolide results in a significant decrease in blood urea nitrogen (BUN), serum creatinine, and acute tubular necrosis (ATN) score, and a nonsignificant increase in tubular apoptosis score in AKI. The protection of omtriptolide against AKI is associated with a decrease in p-ERK and is independent of MKP-1 and proinflammatory cytokines[1]. In a mouse heterotopic tracheal allograft model of obliterative airway disease, omtriptolide attenuates airway obliteration and inhibits accumulation of inflammatory cells, and therefore may have preventive or therapeutic benefits for patients with obliterative airway disease following lung transplantation[2]. Omtriptolide inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. Omtriptolide also markedly reduces the number of myofibroblasts in the bleomycin treatment group[3]. Omtriptolide inhibits in vivo both CD4+Vbeta3+ and CD8+Vbeta3+ T cell (alloreactive T cells in this model) expansion in the spleen by 64.09 and 34.02%, respectively, at the time when Vbeta3+ cell expansion is in the logarithmic phase (day 3 after transplantation)[4].
Animal Admin	Mice: Omtriptolide (0.25 mg/kg per day) is started immediately after the transplant and 10 control mice receive intraperitoneal injections of sterile water each day. The mice are then maintained for 28 days until killing, at which time the mice are administered CO2 inhalation, and cervical dislocation is performed. Trachea is divided for histologic staining and immunohistochemistry [2].
References	[1]. Kim HJ, et al. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun;349(3):518-25. [2]. Leonard CT, et al. PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. J Heart Lung Transplant. 2002 Dec;21(12):1314-8. [3]. Krishna G, et al. PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. Am J Pathol. 2001 Mar;158(3):997-1004. [4]. Chen BJ, et al. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000 Nov 27;70(10):1442-7.

Density	1.49
Melting Point	109-111ºC
Molecular Formula	C₂₄H₂₈O₉
Molecular Weight	460.47400
Exact Mass	460.17300
PSA	127.49000
LogP	1.51880
Storage condition	2-8℃

108-30-5 structure

108-30-5

38748-32-2 structure

38748-32-2

~71%

195883-06-8 structure

195883-06-8

Literature: PIERRE FABRE MEDICAMENT Patent: EP1946758 A1, 2008 ; Location in patent: Page/Page column 8 ;